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Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study

Anthony Faivre 1 Emmanuelle Robinet 2 Maxime Guye 3, 2 Célia Rousseau 4 Adil Maarouf 2, 5, 3 Arnaud Le Troter 2 W Zaaraoui 2 Audrey Rico 2 Lydie Crespy 6 Elisabeth Soulier 2 Sylviane Confort-Gouny 2 Jean Pelletier 2, 7 Sophie Achard 8 Jean-Philippe Ranjeva 2 Bertrand Audoin 2, 9
1 Service Neurologie
2 CRMBM - Centre de résonance magnétique biologique et médicale
3 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Marseille]
4 CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093]
5 Hôpital Maison Blanche
6 Pôle de Neurosciences Cliniques, Department of Neurology
7 APHM - Assistance Publique - Hôpitaux de Marseille
8 GIPSA-VIBS - GIPSA - Vision and Brain Signal Processing
GIPSA-DIS - Département Images et Signal
9 Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM]
Abstract : BACKGROUND: The compensatory effect of brain functional connectivity enhancement in relapsing-remitting multiple sclerosis (RRMS) remains controversial. OBJECTIVE: To characterize the relationships between brain functional connectivity changes and disability progression in RRMS. METHODS: Long-range connectivity, short-range connectivity, and density of connections were assessed using graph theoretical analysis of resting-state functional magnetic resonance imaging (fMRI) data acquired in 38 RRMS patients (disease duration: 120 ± 32 months) and 24 controls. All subjects were explored at baseline and all patients and six controls 2 years later. RESULTS: At baseline, levels of long-range and short-range brain functional connectivity were higher in patients compared to controls. During the follow-up, decrease in connections' density was inversely correlated with disability progression. Post-hoc analysis evidenced differential evolution of brain functional connectivity metrics in patients according to their level of disability at baseline: while patients with lowest disability at baseline experienced an increase in all connectivity metrics during the follow-up, patients with higher disability at baseline showed a decrease in the connectivity metrics. In these patients, decrease in the connectivity metrics was associated with disability progression. CONCLUSION: The study provides two main findings: (1) brain functional connectivity enhancement decreases during the disease course after reaching a maximal level, and (2) decrease in brain functional connectivity enhancement participates in disability progression.
Keywords : Multiple Sclerosis Functional MRI Graph theory crmbm Disability Functional connectivity
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-01425493
Contributor : Monique Bernard <>
Submitted on : Tuesday, January 3, 2017 - 3:55:12 PM
Last modification on : Friday, December 11, 2020 - 2:12:09 PM

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UNIV-AMU | CNRS | U1093 | UNIV-BOURGOGNE | GIPSA | GIPSA-DIS | CRMBM | UGA

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Anthony Faivre, Emmanuelle Robinet, Maxime Guye, Célia Rousseau, Adil Maarouf, et al.. Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study. Multiple Sclerosis Journal, SAGE Publications, 2016, 22 (13), pp.1695--1708. ⟨10.1177/1352458516628657⟩. ⟨hal-01425493⟩

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