Myocardial arterial spin labeling

Frank Kober (1) , Terrence Jao (2) , Thomas Troalen (1) , Krishna S. Nayak (2)

1 CRMBM - Centre de résonance magnétique biologique et médicale
2 Ming Hsieh Department of Electrical Engineering [Los Angeles]

Arterial spin labeling (ASL) is a cardiovascular magnetic resonance (CMR) technique for mapping regional myocardial blood flow. It does not require any contrast agents, is compatible with stress testing, and can be performed repeatedly or even continuously. ASL-CMR has been performed with great success in small-animals, but sensitivity to date has been poor in large animals and humans and remains an active area of research. This review paper summarizes the development of ASL-CMR techniques, current state-of-the-art imaging methods, the latest findings from pre-clinical and clinical studies, and future directions. We also explain how successful developments in brain ASL and small-animal ASL-CMR have helped to inform developments in large animal and human ASL-CMR.

Keywords: myocardial perfusion; Myocardial perfusion; Cardiovascular magnetic resonance; Ischemic heart disease; arterial spin labeling; Cardiovascular magnetic resonance; crmbm; Ischemic heart disease

Domains: Life Sciences [q-bio]; Bioengineering

Frank Kober, Terrence Jao, Thomas Troalen, Krishna S. Nayak. Myocardial arterial spin labeling. Journal of Cardiovascular Magnetic Resonance, 2016, 18 (1), pp.22. ⟨10.1186/s12968-016-0235-4⟩. ⟨hal-01425517⟩