Skip to Main content Skip to Navigation
Journal articles

Magnetization transfer from inhomogeneously broadened lines (ihMT): Improved imaging strategy for spinal cord applications

Abstract : Purpose Inhomogeneous magnetization transfer (ihMT) shows great promise for specific imaging of myelinated tissues. Whereas the ihMT technique has been previously applied in brain applications, the current report presents a strategy for cervical spinal cord (SC) imaging free of cerebrospinal fluid (CSF) pulsatility artifacts. Methods A pulsed ihMT preparation was combined with a single-shot HASTE readout. Electrocardiogram (ECG) synchronization was used to acquire all images during the quiescent phase of SC motion. However ihMT signal quantification errors may occur when a variable recovery delay is introduced in the sequence as a consequence of variable cardiac cycle. A semiautomatic retrospective correction algorithm, based on repetition time (TR) -matching, is proposed to correct for signal variations of long T1-components (e.g., CSF). Results The proposed strategy combining ECG synchronization and retrospective data pairing led to clean SC images free of CSF artifacts. Lower variability of the ihMT metrics were obtained with the correction algorithm, and allowed for shorter TR to be used, hence improving signal-to-noise ratio efficiency. Conclusion The proposed methodology enabled faster acquisitions, while offering robust ihMT quantification and exquisite SC image quality. This opens great perspectives for widening the in vivo characterization of SC physiopathology using MRI, such as studying white matter tracts microstructure or impairment in degenerative pathologies. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-01425518
Contributor : Monique Bernard <>
Submitted on : Tuesday, January 3, 2017 - 3:56:16 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:26 PM

Identifiers

Collections

Citation

Olivier M. Girard, Virginie Callot, Valentin H. Prevost, Benjamin Robert, Manuel Taso, et al.. Magnetization transfer from inhomogeneously broadened lines (ihMT): Improved imaging strategy for spinal cord applications. Magnetic Resonance in Medicine, Wiley, 2016, pp.n/a--n/a. ⟨10.1002/mrm.26134⟩. ⟨hal-01425518⟩

Share

Metrics

Record views

159