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Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial

Alexandre Foure 1 Kazunori Nosaka Marguerite Gastaldi 2 Jean-Pierre Mattei 3, 1 Hélène Boudinet 1 Maxime Guye 4, 1 Christophe Vilmen 1 Yann Le Fur 1 David Bendahan 1 Julien Gondin 1
1 CRMBM - Centre de résonance magnétique biologique et médicale
2 NORT - Nutrition, obésité et risque thrombotique
3 Service de Rhumatologie [CHU Sainte Marguerite]
4 CEMEREM - Centre d'Exploration Métabolique par Résonance Magnétique [Marseille]
Abstract : BACKGROUND & AIMS: Branched-chain amino acids promote muscle-protein synthesis, reduce protein oxidation and have positive effects on mitochondrial biogenesis and reactive oxygen species scavenging. The purpose of the study was to determine the potential benefits of branched-chain amino acids supplementation on changes in force capacities, plasma amino acids concentration and muscle metabolic alterations after exercise-induced muscle damage. METHODS: (31)P magnetic resonance spectroscopy and biochemical analyses were used to follow the changes after such damage. Twenty six young healthy men were randomly assigned to supplemented branched-chain amino acids or placebo group. Knee extensors maximal voluntary isometric force was assessed before and on four days following exercise-induced muscle damage. Concentrations in phosphocreatine [PCr], inorganic phosphate [Pi] and pH were measured during a standardized rest-exercise-recovery protocol before, two (D2) and four (D4) days after exercise-induced muscle damage. RESULTS: No significant difference between groups was found for changes in maximal voluntary isometric force (-24% at D2 and -21% at D4). Plasma alanine concentration significantly increased immediately after exercise-induced muscle damage (+25%) in both groups while concentrations in glycine, histidine, phenylalanine and tyrosine decreased. No difference between groups was found in the increased resting [Pi] (+42% at D2 and +34% at D4), decreased resting pH (-0.04 at D2 and -0.03 at D4) and the slower PCr recovery rate (-18% at D2 and -24% at D4). CONCLUSIONS: The damaged muscle was not able to get benefits out of the increased plasma branched-chain amino acids availability to attenuate changes in indirect markers of muscle damage and muscle metabolic alterations following exercise-induced muscle damage.
Keywords : crmbm Double blind randomized placebo controlled trial Exercise induced-muscle damage Magnetic Resonance Spectroscopy
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Submitted on : Tuesday, January 3, 2017 - 3:56:18 PM
Last modification on : Wednesday, November 3, 2021 - 9:11:44 AM

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Alexandre Foure, Kazunori Nosaka, Marguerite Gastaldi, Jean-Pierre Mattei, Hélène Boudinet, et al.. Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial. Clinical Nutrition, Elsevier, 2016, 35 (1), pp.83--94. ⟨10.1016/j.clnu.2015.03.014⟩. ⟨hal-01425519⟩

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