SLX4 gains weight with SUMO in genome maintenance

Jean-Hugues Guervilly (1) , Pierre-Henri Gaillard (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille

Replication stress has emerged as a key driver of oncogenesis but also represents an Achilles’ heel of cancer cells. Newly reported SUMO binding and SUMO ligase functions of the DNA repair SLX4 protein that impact the outcome of replication stress open new avenues for investigating roles played by SLX4 in tumorigenesis.

Domaines: Biochimie, Biologie Moléculaire; Biologie cellulaire; Cancer

Jean-Hugues Guervilly, Pierre-Henri Gaillard. SLX4 gains weight with SUMO in genome maintenance. Molecular & Cellular Oncology, 2016, 3, pp.e1008297. ⟨10.1080/23723556.2015.1008297⟩. ⟨hal-01429047⟩