Gabapentin for Tinnitus: A Systematic Review, American Journal of Audiology, vol.20, issue.2, pp.151-158, 2011. ,
DOI : 10.1044/1059-0889(2011/10-0041)
The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters, Science Signaling, vol.7, issue.334, 2014. ,
DOI : 10.1126/scisignal.2005365
Modulation of inhibitory and excitatory synaptic transmission in rat inferior colliculus after unilateral cochleectomy: An in situ and immunofluorescence study, Neuroscience, vol.141, issue.3, pp.1193-1207, 2006. ,
DOI : 10.1016/j.neuroscience.2006.04.058
URL : https://hal.archives-ouvertes.fr/hal-00092469
Cochlear implants and tinnitus, Prog. Brain Res, vol.166, issue.07, pp.347-355, 2007. ,
DOI : 10.1016/S0079-6123(07)66033-6
The Prevalence and Onset of Gaze Modulation of Tinnitus and Increased Sensitivity to Noise After Translabyrinthine Vestibular Schwannoma Excision, Otology & Neurotology, vol.27, issue.2, pp.220-224, 2006. ,
DOI : 10.1097/01.mao.0000172412.87778.28
Effects of acoustic trauma on the auditory system of the rat: The role of microglia, Neuroscience, vol.303, pp.299-311, 2015. ,
DOI : 10.1016/j.neuroscience.2015.07.004
The Brain Stem of the Cat: A Cytoarchitectonic Atlas with Stereotaxic Coordinates, 1968. ,
Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2, Proceedings of the National Academy of Sciences, vol.110, issue.1, pp.348-353, 2013. ,
DOI : 10.1073/pnas.1213680110
Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury, Nature Medicine, vol.26, issue.3, pp.302-307, 2010. ,
DOI : 10.1038/nm.2107
Synaptic gain control and homeostasis, Current Opinion in Neurobiology, vol.13, issue.5, pp.560-567, 2003. ,
DOI : 10.1016/j.conb.2003.09.007
Encoding Intensity in Ventral Cochlear Nucleus Following Acoustic Trauma: Implications for Loudness Recruitment, Journal of the Association for Research in Otolaryngology, vol.43, issue.217, pp.5-22, 2001. ,
DOI : 10.1007/s10162-008-0142-y
Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons, Journal of Neuroscience, vol.33, issue.39, pp.15488-15503, 2013. ,
DOI : 10.1523/JNEUROSCI.5889-12.2013
Neocortical and hippocampal neuron and glial cell numbers in the rhesus monkey, The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, vol.344, issue.3, pp.330-340, 2007. ,
DOI : 10.1002/ar.20504
On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro, Science, vol.298, issue.5597, pp.1418-1421, 2002. ,
DOI : 10.1126/science.1076510
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain, Nature, vol.59, issue.7070, pp.1017-1021, 1038. ,
DOI : 10.1038/nature04223
HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design, Annual Review of Neuroscience, vol.29, issue.1, pp.307-323, 2006. ,
DOI : 10.1146/annurev.neuro.28.061604.135751
Synapse-specific control of synaptic efficacy at the terminals of a single neuron, Nature, vol.392, issue.6671, pp.82-86, 1998. ,
DOI : 10.1038/32176
Altered chloride homeostasis in neurological disorders: a new target, Current Opinion in Pharmacology, vol.7, issue.1, pp.93-99, 2007. ,
DOI : 10.1016/j.coph.2006.11.005
Treating pathological pain: is KCC2 the key to the gate?, Expert Review of Neurotherapeutics, vol.13, issue.5, pp.469-471, 2013. ,
DOI : 10.1586/ern.13.40
Neurogenesis and astrogenesis contribution to recovery of vestibular functions in the adult cat following unilateral vestibular neurectomy: cellular and behavioral evidence, Neuroscience, vol.164, issue.4, pp.1444-1456, 2009. ,
DOI : 10.1016/j.neuroscience.2009.09.048
GABAA Receptor Agonist and Antagonist Alter Vestibular Compensation and Different Steps of Reactive Neurogenesis in Deafferented Vestibular Nuclei of Adult Cats, Journal of Neuroscience, vol.33, issue.39, pp.15555-15566, 2013. ,
DOI : 10.1523/JNEUROSCI.5691-12.2013
Neurogenic Potential of the Vestibular Nuclei and Behavioural Recovery Time Course in the Adult Cat Are Governed by the Nature of the Vestibular Damage, PLoS ONE, vol.14, issue.8, 2011. ,
DOI : 10.1371/journal.pone.0022262.s003
BDNF Signaling Promotes Vestibular Compensation by Increasing Neurogenesis and Remodeling the Expression of Potassium-Chloride Cotransporter KCC2 and GABAA Receptor in the Vestibular Nuclei, Journal of Neuroscience, vol.36, issue.23, pp.6199-6212, 2016. ,
DOI : 10.1523/JNEUROSCI.0945-16.2016
Microglia Control Neuronal Network Excitability via BDNF Signalling, Neural Plasticity, vol.18, issue.5, p.429815, 2013. ,
DOI : 10.1126/science.1094925
URL : http://doi.org/10.1155/2013/429815
Reduction of voltage-dependent magnesium block of N-methyl-d-aspartate receptor-mediated current by in vivo axonal injury, Neuroscience, vol.96, issue.2, pp.385-392, 2000. ,
DOI : 10.1016/S0306-4522(99)00553-9
Chloride extrusion enhancers as novel therapeutics for neurological diseases, Nature Medicine, vol.53, issue.11, pp.1524-1528, 2013. ,
DOI : 10.1038/nm.3356
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005788
Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury, Journal of Neuroinflammation, vol.8, issue.1, pp.110-120, 2011. ,
DOI : 10.1523/JNEUROSCI.2269-10.2010
URL : http://doi.org/10.1186/1742-2094-8-110
Effects of Chronic Infusion of a GABAA Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig, Journal of Pharmacology and Experimental Therapeutics, vol.313, issue.3, pp.1126-1135, 2005. ,
DOI : 10.1124/jpet.104.082172
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability The Yin and Yang of NMDA receptor signalling, Nature Trends Neurosci, vol.465, issue.2602, pp.1070-1074, 2003. ,
Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia, Stroke, vol.41, issue.3, pp.151-159, 2010. ,
DOI : 10.1161/STROKEAHA.109.570424
The effects of alprazolam on tinnitus: a cross-over randomized clinical trial, Med. Sci. Monit, vol.15, pp.55-60, 2009. ,
Use of Alprazolam for Relief of Tinnitus: A Double-blind Study, Archives of Otolaryngology - Head and Neck Surgery, vol.119, issue.8, pp.842-84501880200042006, 1993. ,
DOI : 10.1001/archotol.1993.01880200042006
rheostasis, disease susceptibility, therapeutic target, Journal of Neurophysiology, vol.115, issue.1, pp.8-18, 2016. ,
DOI : 10.1152/jn.00865.2015
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760510
Cation-chloride cotransporters in neuronal development, plasticity and disease, Nature Reviews Neuroscience, vol.345, issue.10, pp.637-654, 1038. ,
DOI : 10.1038/nature04404
Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus, The Journal of Physiology, vol.84, issue.22, pp.5065-5078, 2014. ,
DOI : 10.1113/jphysiol.2014.278572
Plasticity of spontaneous neural activity in the dorsal cochlear nucleus after intense sound exposure, Hearing Research, vol.147, issue.1-2, pp.282-292, 2000. ,
DOI : 10.1016/S0378-5955(00)00138-6
Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses, J. Neurosci, vol.22, pp.1328-1337, 2002. ,
Spontaneous spike discharges from single units in the cochlear nucleus after destruction of the cochlea, Experimental Neurology, vol.16, issue.2, pp.119-130, 1966. ,
DOI : 10.1016/0014-4886(66)90091-4
Homeostasis, Inflammation, and Disease Susceptibility, Cell, vol.160, issue.5, pp.816-827, 2015. ,
DOI : 10.1016/j.cell.2015.02.010
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369762
Presynaptic activity regulates Na+ channel distribution at the axon initial segment, Nature, vol.277, issue.7301, pp.1075-1078, 2010. ,
DOI : 10.1038/nature09087
Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2, Journal of Biological Chemistry, vol.282, issue.41, pp.29777-29784, 2007. ,
DOI : 10.1074/jbc.M705053200
Changes in TNF??, NF??B and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation, Journal of Neuroinflammation, vol.7, issue.1, pp.91-101, 2010. ,
DOI : 10.1186/1742-2094-7-91
Long-term behavioural and molecular alterations associated with maternal separation in rats, European Journal of Neuroscience, vol.896, issue.Suppl. 2, pp.3091-3098, 2007. ,
DOI : 10.1111/j.1460-9568.2007.05522.x
Expression of doublecortin, a neuronal migration protein, in unipolar brush cells of the vestibulocerebellum and dorsal cochlear nucleus of the adult rat, Neuroscience, vol.202, pp.169-183, 2012. ,
DOI : 10.1016/j.neuroscience.2011.12.013
The prevalence of tinnitus and the relationship with neuroticism in a middle-aged UK population, Journal of Psychosomatic Research, vol.76, issue.1, pp.56-60, 2014. ,
DOI : 10.1016/j.jpsychores.2013.08.018
GAD levels and muscimol binding in rat inferior colliculus following acoustic trauma, Hearing Research, vol.147, issue.1-2, pp.251-260, 2000. ,
DOI : 10.1016/S0378-5955(00)00135-0
Tinnitus and pain, Prog. Brain Res. Neuroscience, vol.166, issue.164, pp.47-53, 2007. ,
DOI : 10.1016/S0079-6123(07)66004-X
Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury, J. Neurosci, vol.22, pp.4412-4417, 2002. ,
An integrative model of tinnitus based on a central gain controlling neural sensitivity, Neuroscience & Biobehavioral Reviews, vol.35, issue.5, 2011. ,
DOI : 10.1016/j.neubiorev.2010.11.003
Changes in spontaneous neural activity immediately after an acoustic trauma: implications for neural correlates of tinnitus, Hearing Research, vol.183, issue.1-2, pp.137-153, 2003. ,
DOI : 10.1016/S0378-5955(03)00225-9
Tinnitus-related neural activity: Theories of generation, propagation, and centralization, Hearing Research, vol.295, pp.161-171, 2012. ,
DOI : 10.1016/j.heares.2012.09.010
Spectrally enhanced acoustic environment disrupts frequency representation in cat auditory cortex, Nature Neuroscience, vol.110, issue.7, pp.932-939, 1038. ,
DOI : 10.1038/nn1720
Neural Changes in Cat Auditory Cortex After a Transient Pure-Tone Trauma, Journal of Neurophysiology, vol.90, issue.4, pp.2387-2401, 2003. ,
DOI : 10.1152/jn.00139.2003
Cation???chloride co-transporters in neuronal communication, development and trauma, Trends in Neurosciences, vol.26, issue.4, pp.199-206, 2003. ,
DOI : 10.1016/S0166-2236(03)00068-7
Passive exposure of adult cats to bandlimited tone pip ensembles or noise leads to long-term response suppression in auditory cortex, Hearing Research, vol.277, issue.1-2, pp.117-126, 2011. ,
DOI : 10.1016/j.heares.2011.02.002
Effects of passive, moderate-level sound exposure on the mature auditory cortex: Spectral edges, spectrotemporal density, and real-world noise, Hearing Research, vol.296, pp.121-130, 2013. ,
DOI : 10.1016/j.heares.2012.11.006
Tinnitus and cochlear implantation, International Journal of Audiology, vol.103, issue.6, pp.245-251, 2004. ,
DOI : 10.1016/0168-0102(90)90031-9
Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity, Cell, vol.138, issue.3, pp.525-536, 2009. ,
DOI : 10.1016/j.cell.2009.05.031
Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig, J. Neurophysiol, vol.74, pp.2087-2099, 1995. ,
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2, Journal of Neuroscience, vol.24, issue.19, pp.4683-4691, 2004. ,
DOI : 10.1523/JNEUROSCI.5265-03.2004
BDNF Has Opposite Effects on the Quantal Amplitude of Pyramidal Neuron and Interneuron Excitatory Synapses, Neuron, vol.21, issue.3, pp.521-530, 1998. ,
DOI : 10.1016/S0896-6273(00)80563-2
Differential [14C]2-deoxyglucose uptake after deafferentation of the mammalian auditory pathway ??? a model for examining tinnitus, Brain Research, vol.194, issue.2, pp.511-516, 1980. ,
DOI : 10.1016/0006-8993(80)91233-0
Development of tinnitus-related neuronal hyperactivity through homeostatic plasticity after hearing loss: a computational model, European Journal of Neuroscience, vol.78, issue.11, pp.3124-3138, 2006. ,
DOI : 10.1111/j.1460-9568.2006.04774.x
Somatosensory influence on the cochlear nucleus and beyond, Hearing Research, vol.216, issue.217, pp.90-99, 2006. ,
DOI : 10.1016/j.heares.2006.01.006
Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo, Journal of Neuroscience, vol.35, issue.21, pp.8291-8296, 2015. ,
DOI : 10.1523/JNEUROSCI.5205-14.2015
Responses of Ventral Cochlear Nucleus Neurons to Contralateral Sound After Conductive Hearing Loss, Journal of Neurophysiology, vol.94, issue.6, pp.4234-4243, 2005. ,
DOI : 10.1152/jn.00401.2005
Plastic Changes in Glycine and GABA Release and Uptake in Adult Brain Stem Auditory Nuclei after Unilateral Middle Ear Ossicle Removal and Cochlear Ablation, Experimental Neurology, vol.151, issue.2, pp.273-2886812, 1998. ,
DOI : 10.1006/exnr.1998.6812
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus, Nature, vol.26, issue.7105, pp.929-933, 1038. ,
DOI : 10.1038/nature05028
Protocols for studying adult neurogenesis: insights and recent developments, Regenerative Medicine, vol.2, issue.1, pp.51-62, 2007. ,
DOI : 10.2217/17460751.2.1.51
New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat, European Journal of Neuroscience, vol.509, issue.1, pp.47-58, 2007. ,
DOI : 10.1111/j.1460-9568.2006.05267.x
Stress axis plasticity during vestibular compensation in the adult cat, Neuroscience, vol.160, issue.4, 2009. ,
DOI : 10.1016/j.neuroscience.2009.02.070
Downregulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity, PLoS ONE, vol.9, 2014. ,
IFN-?? receptor signaling mediates spinal microglia activation driving neuropathic pain, Proceedings of the National Academy of Sciences, vol.106, issue.19, pp.8032-8037, 2009. ,
DOI : 10.1073/pnas.0810420106
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683100
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same, Trends in Neurosciences, vol.22, issue.5, pp.221-227, 1999. ,
DOI : 10.1016/S0166-2236(98)01341-1
The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses, Cell, vol.135, issue.3, pp.422-435, 2008. ,
DOI : 10.1016/j.cell.2008.10.008
Activity-dependent scaling of quantal amplitude in neocortical neurons, Nature, vol.391, issue.6670, pp.892-896, 1998. ,
DOI : 10.1038/36103
Thinking Globally, Acting Locally, Neuron, vol.21, issue.5, pp.933-935, 1998. ,
DOI : 10.1016/S0896-6273(00)80607-8
Homeostatic plasticity in the developing nervous system, Nature Reviews Neuroscience, vol.5, issue.2, pp.97-107, 2004. ,
DOI : 10.1038/nrn1327
Deafness disrupts chloride transporter function and inhibitory synaptic transmission, J. Neurosci, vol.23, pp.7516-7524, 2003. ,
Homeostatic plasticity and STDP: keeping a neuron's cool in a fluctuating world, Frontiers in Synaptic Neuroscience, vol.2, 2010. ,
DOI : 10.3389/fnsyn.2010.00005
New stereological methods for counting neurons, Neurobiology of Aging, vol.14, issue.4, pp.275-285, 1991. ,
DOI : 10.1016/0197-4580(93)90112-O
Emerging links between homeostatic synaptic plasticity and neurological disease, Frontiers in Cellular Neuroscience, vol.7, 2013. ,
DOI : 10.3389/fncel.2013.00223
URL : http://doi.org/10.3389/fncel.2013.00223
Recovery of Head Postural Control Following Unilateral Vestibular Neurectomy in the Cat: Neck Muscle Activity and Neuronal Correlates in Deiters' Nuclei, Acta Oto-Laryngologica, vol.45, issue.sup509, pp.1-19, 1993. ,
DOI : 10.3109/00016489309130556
Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat, Experimental Brain Research, vol.100, issue.11, pp.477-487, 2011. ,
DOI : 10.1007/s00221-010-2491-0
Cell proliferation in the cochlear nucleus following acoustic trauma in rat, Neuroscience, vol.303, pp.524-534, 2015. ,
DOI : 10.1016/j.neuroscience.2015.07.033
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