Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

An innovative floating gastro retentive dosage system: Formulation and in vitro evaluation

Abstract : Over the years, different formulation technologies intended for gastro retentive dosage delivery were investigated and patented. The aim of this study was to develop an innovative floating gastro retentive dosage form (GRDF). The developed technology induces a low-density dosage form containing high active pharmaceutical ingredient (API) concentration by using a hydrophobic dusty powder excipient under specific conditions. The new dosage form was obtained by state of the art wet granulation manufacturing process. An experimental design using a discrete variable and four mixture variables was conducted in order to optimize API concentration and buoyancy of the new dosage form. An apparatus was developed to measure the apparent density of floating tablet. The GRDF was characterized for apparent density, buoyancy, porosity and dissolution using in vitro experimentations.
Document type :
Journal articles
Complete list of metadata

Cited literature [25 references]  Display  Hide  Download
Contributor : Maxime NICOLAS Connect in order to contact the contributor
Submitted on : Tuesday, January 17, 2017 - 4:08:34 PM
Last modification on : Thursday, December 16, 2021 - 3:56:41 AM




Christophe Sauzet, M Claeys-Bruno, Maxime Nicolas, J Kister, P Piccerelle, et al.. An innovative floating gastro retentive dosage system: Formulation and in vitro evaluation. International Journal of Pharmaceutics, Elsevier, 2009, 378, pp.23 - 29. ⟨10.1016/j.ijpharm.2009.05.027⟩. ⟨hal-01432996⟩



Record views