B. Abrahamsson, M. Alpsten, and M. Hugosson, Absorption, gastrointestinal transit , and tablet erosion of felodipine extended-release (ER) tablets, Pharmaceutical Research, vol.10, issue.5, pp.709-714, 1993.
DOI : 10.1023/A:1018959732744

P. Bardonnet, V. Faivre, W. Pugh, J. Piffaretti, and F. Falson, Gastroretentive dosage forms: Overview and special case of Helicobacter pylori, Journal of Controlled Release, vol.111, issue.1-2, pp.1-18, 2006.
DOI : 10.1016/j.jconrel.2005.10.031

G. Box and K. Wilson, On the Experimental Attainment of Optimum Conditions, J. R. Stat. Soc. B, vol.13, pp.1-45, 1951.
DOI : 10.1007/978-1-4612-4380-9_23

J. Cornell, Experiments with Mixtures: Designs, Models, and the Analysis of Mixture Data, 1990.
DOI : 10.1002/9781118204221

W. Curatolo and J. Lo, US Patent no, 1988.

S. Desai and S. Bolton, A floating controlled-release drug delivery systems: in vitro?in vivo evaluation, Pharmaceutical Research, vol.10, issue.9, pp.1321-1325, 1993.
DOI : 10.1023/A:1018921830385

V. Fedorov, Theory of Optimal Experiments, 1972.

M. Fukuda, N. Peppas, and J. Mcginity, Floating hot-melt extruded tablets for gastroretentive controlled drug release system, Journal of Controlled Release, vol.115, issue.2, pp.121-129, 2006.
DOI : 10.1016/j.jconrel.2006.07.018

S. J. Hwang, H. Park, and K. Park, Gastric retentive drug-delivery systems, Ther. Drug Carrier Syst, vol.15, pp.243-284, 1998.

L. Kagan and A. Hoffman, Systems for region selective drug delivery in the gastrointestinal tract: biopharmaceutical considerations, Expert Opinion on Drug Delivery, vol.4, issue.6, pp.681-692, 2008.
DOI : 10.1080/03639040500271837

R. Khosla, L. Feely, and S. G. Davis, Gastrointestinal transit of non-disintegrating tablets in fed subjects, International Journal of Pharmaceutics, vol.53, issue.2, pp.107-117, 1989.
DOI : 10.1016/0378-5173(89)90234-2

J. Kiefer and J. Wolfowitz, Optimum Designs in Regression Problems, The Annals of Mathematical Statistics, vol.30, issue.2, pp.271-294, 1959.
DOI : 10.1214/aoms/1177706252

URL : http://projecteuclid.org/download/pdf_1/euclid.aoms/1177706252

A. Klausner, S. Eyal, E. Lavy, M. Friedman, and A. Hoffman, Novel levodopa gastroretentive dosage form: in-vivo evaluation in dogs, Journal of Controlled Release, vol.88, issue.1, pp.117-126, 2003.
DOI : 10.1016/S0168-3659(02)00487-X

T. Mitchell, An algorithm for the construction of D-optimal experimental designs, Technometrics, vol.16, pp.203-210, 1974.

O. Reilly, S. Wilson, C. Hardy, and J. , The influence of food on the gastric emptying of multiparticulate dosage forms, International Journal of Pharmaceutics, vol.34, issue.3, pp.213-216, 1987.
DOI : 10.1016/0378-5173(87)90182-7

S. Sangekar, W. A. Vadino, I. Chaudry, A. Parr, R. Beihn et al., Evaluation of the effect of food and specific gravity of tablets on gastric retention time, International Journal of Pharmaceutics, vol.35, issue.3, pp.187-197, 1987.
DOI : 10.1016/0378-5173(87)90129-3

H. Scheffé, Simplex-centroid design for experiments with mixtures, J. R. Stat. Soc. B, vol.25, pp.235-263, 1963.

A. Streubel, J. Siepmann, and R. Bodmeier, Floating microparticles based on low density foam powder, International Journal of Pharmaceutics, vol.241, issue.2, pp.279-292, 2002.
DOI : 10.1016/S0378-5173(02)00241-7

A. Streubel, J. Siepmann, and R. Bodmeier, Floating matrix tablets based on low density foam powder: effects of formulation and processing parameters on drug release, European Journal of Pharmaceutical Sciences, vol.18, issue.1, pp.37-45, 2003.
DOI : 10.1016/S0928-0987(02)00223-3

A. Streubel, J. Siepmann, and R. Bodmeier, Multiple unit gastroretentive drug delivery systems: A new preparation method for low density microparticles, Journal of Microencapsulation, vol.57, issue.1, pp.329-347, 2003.
DOI : 10.3109/03639048409064653

A. Struebel, J. Siepmann, and R. Bodmeier, Gastroretentive drug delivery systems, Expert Opinion on Drug Delivery, vol.36, issue.2, pp.217-233, 2006.
DOI : 10.1016/0378-5173(94)90236-4

J. Timmermans, Floating Hydrophillic Matrix Dosage Forms for Oral use: Factors Controlling Their Buoyancy and Gastric Residence Capabilities, 1991.

J. Timmermans and A. Moës, How well do floating dosage forms float? Int, J. Pharm, vol.62, pp.207-216, 1990.
DOI : 10.1016/0378-5173(90)90234-u

J. Timmermans and A. Moës, Measuring the resultant-weight of an immersed test material: I. Validation of an apparatus and a method dedicated to pharmaceutical applications, Acta Pharm. Technol, vol.36, pp.171-175, 1990.

J. Timmermans and A. Moës, Measuring the resultant-weigthof an immersed test material: II. Examples of kinetic determination applied to monolithic dosage forms, Acta Pharm. Technol, vol.36, pp.176-180, 1990.