Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases

Alda Lisa Concia (1) , Maria Rosa Beccia (2) , Maylis Orio (1) , Francine Terra Ferre (3) , Marciela Scarpellini (3) , Frédéric Biaso (2) , Bruno Guigliarelli (2, 4) , Marius Réglier (1) , A. Jalila Simaan (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 BIP - Bioénergétique et Ingénierie des Protéines
3 Instituto de Química
4 AMU - Aix Marseille Université

We report here two copper complexes as first functional models for lytic polysaccharide monooxygenases, mononuclear copper-containing enzymes involved in recalcitrant polysaccharide breakdown. These complexes feature structural and spectroscopic properties similar to those of the enzyme. In addition, they catalyze oxidative cleavage of the model substrate p-nitrophenyl-β-d-glucopyranoside. More importantly, a particularly stable copper(II) hydroperoxide intermediate is detected in the reaction conditions

Domains: Chemical Sciences; Chemical Sciences; Inorganic chemistry

Alda Lisa Concia, Maria Rosa Beccia, Maylis Orio, Francine Terra Ferre, Marciela Scarpellini, et al.. Copper Complexes as Bioinspired Models for Lytic Polysaccharide Monooxygenases. Inorganic Chemistry, 2017, 56 (3), pp.1023 - 1026. ⟨10.1021/acs.inorgchem.6b02165⟩. ⟨hal-01440965⟩