Exploring the successive waves of cortical folding in the developing brain using MRI and spectral analysis of gyrification

Jessica Dubois (1, 2, 3) , David Germanaud (4, 5, 1, 6, 7) , Hugo Angleys (2) , François Leroy (2) , Clara Fischer (8) , Jessica Lebenberg (9) , François Lazeyras (10) , Ghislaine Dehaene-Lambertz (2, 11) , Lucie Hertz-Pannier (6) , Jean-François Mangin (12, 11) , Petra S. Huppi (13) , Julien Lefèvre (14, 15)

1 IFR49 - Neurospin - CEA
2 UNICOG-U992 - Neuroimagerie cognitive - Psychologie cognitive expérimentale
3 UP11 - Université Paris-Sud - Paris 11
4 Service de neurologie pédiatrique et maladies métaboliques
5 UPD7 - Université Paris Diderot - Paris 7
6 U1129 - Epilepsies de l'Enfant et Plasticité Cérébrale
7 UPD5 - Université Paris Descartes - Paris 5
8 Centre d'Acquisition et de Traitement des Images [Paris]
9 LIB - Laboratoire d'Imagerie Biomédicale
10 Department of Radiology
11 NEUROSPIN - Service NEUROSPIN
12 LNAO - Laboratoire de Neuroimagerie Assistée par Ordinateur
13 Department of Neurology, Children's Hospital [Boston]
14 LSIS - Laboratoire des Sciences de l'Information et des Systèmes
15 INT - Institut de Neurosciences de la Timone

In the developing human brain, gyrification is a complex process going through the successive appearance of primary folds (from 20 weeks of gestational age GA), secondary folds (from 32w GA) and tertiary folds (around term age). While this sequence is finely described in fetuses and preterm newborns of different ages using MRI and folding indices, there is still no fully objective assessment of the folding stage at the individual level. We examined the potential of a new method of spectral analysis of gyrification (SPANGY) that was applied to cortical surfaces of 26 preterm newborns, 9 full-term newborns and 17 infants to quantify the spatial-frequency structure of folding. Based on modelling approaches, we unraveled 4 periods along the developmental sequence from 27 to 62w GA, with relevant timepoints around 31w, 36-38w, and 44-47w GA. These periods showed specific folding features, with spatial patterns of increasing frequencies.

Domains: Life Sciences [q-bio]; Development Biology; Morphogenesis; Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology; Life Sciences [q-bio]; Bioengineering; Imaging

Jessica Dubois, David Germanaud, Hugo Angleys, François Leroy, Clara Fischer, et al.. Exploring the successive waves of cortical folding in the developing brain using MRI and spectral analysis of gyrification. 13th IEEE International Symposium on Biomedical Imaging (ISBI 2016), Apr 2016, Prague, Czech Republic. ⟨10.1109/ISBI.2016.7493259⟩. ⟨hal-01458746⟩