Characterization and angiogenic potential of xenogeneic bone grafting materials: Role of periodontal ligament cells - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Dental Materials Journal Année : 2016

Characterization and angiogenic potential of xenogeneic bone grafting materials: Role of periodontal ligament cells

Résumé

Adequate revascularization is a prerequisite for successful healing of periodontal bone defects. This study characterized three different xenogeneic bone grafting materials: Gen-Os of equine and porcine origins, and anorganic Bio-Oss. We also investigated their angiogenic potential. All materials were composed of poorly crystalline calcium oxide phosphate, with Bio-Oss exhibiting a carbonated phase and larger particle size and both Gen-Os showing the presence of collagen. Both Gen-Os materials significantly enhanced vascular endothelial growth factor (VEGF) secretion by PDL cells. A significant increase in endothelial cell proliferation was observed in cultures with both Gen-Os conditioned media, but not with that of Bio-Oss. Finally, angiogenesis was stimulated by both Gen-Os conditioned media as demonstrated by an increased formation of capillary-like structures. Taken together, these findings indicate an enhanced angiogenic potential of both Gen-Os bone grafting materials when applied on PDL cells, most likely by increasing VEGF production.

Domaines

Biomatériaux

Dates et versions

hal-01458934 , version 1 (13-02-2017)

Identifiants

Citer

Charlotte Rombouts, Charlotte Jeanneau, Josette Camilleri, Patrick Laurent, Imad About. Characterization and angiogenic potential of xenogeneic bone grafting materials: Role of periodontal ligament cells. Dental Materials Journal, 2016, 35 (6), pp.900-907. ⟨10.4012/dmj.2016-005⟩. ⟨hal-01458934⟩
21 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More