Rapid and efficient synthesis of 2-substituted-tetrahydropyrido[3,4-b]quinoxalines using TDAE strategy

Omar Khoumeri (1) , Marc Montana (2, 1) , Thierry Terme (1) , Patrice Vanelle (1)

1 ICR - Institut de Chimie Radicalaire
2 APHM - Assistance Publique - Hôpitaux de Marseille

We report herein an original and rapid synthesis of substituted 2-tosyl-1,2,3,4-tetrahydropyrido[3,4-b]quinoxaline derivatives by TDAE strategy from 2,3-bis(bromomethyl)quinoxaline and N-(toluenesulfonyl)benzylimines. (C) 2012 Elsevier Ltd. All rights reserved.

Domaines: Chimie

Omar Khoumeri, Marc Montana, Thierry Terme, Patrice Vanelle. Rapid and efficient synthesis of 2-substituted-tetrahydropyrido[3,4-b]quinoxalines using TDAE strategy. Tetrahedron Letters, 2012, 53 (19), pp.2410--2413. ⟨10.1016/j.tetlet.2012.02.119⟩. ⟨hal-01460359⟩