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New pyrazole derivatives of potential biological activity

Abstract : 5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde (1) was reacted with hydrazine hydrate and thiosemicarbazide to afford the corresponding hydrazones 2 and thiosemicarbazones 4. The latter compounds were used to obtain the pyrazole derivatives 3, 5-7. A series of azines 8a-e were obtained by reacting 2 with aromatic aldehydes. Potassium permanganate oxidation of 1 gave the acid 9, which was transformed into the corresponding acid azide 11 then used to prepare diverse urea derivatives 13-18 via Curtius reaction.
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Submitted on : Tuesday, February 7, 2017 - 4:35:32 PM
Last modification on : Friday, March 8, 2019 - 2:52:07 PM

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Abdel-Rahman Farghaly, Sabah Esmail, Ali Abdel-Hafez, Patrice Vanelle, Hussein El-Kashef. New pyrazole derivatives of potential biological activity. Arkivoc, 2012, pp.228--241. ⟨hal-01460366⟩

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