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Journal Articles ARKIVOC - Online Journal of Organic Chemistry Year : 2012

New pyrazole derivatives of potential biological activity

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Abdel-Rahman Farghaly
  • Function : Author
Sabah Esmail
  • Function : Author
Ali Abdel-Hafez
  • Function : Author
Patrice Vanelle
  • Function : Author
  • PersonId : 973296

Abstract

5-Chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxaldehyde (1) was reacted with hydrazine hydrate and thiosemicarbazide to afford the corresponding hydrazones 2 and thiosemicarbazones 4. The latter compounds were used to obtain the pyrazole derivatives 3, 5-7. A series of azines 8a-e were obtained by reacting 2 with aromatic aldehydes. Potassium permanganate oxidation of 1 gave the acid 9, which was transformed into the corresponding acid azide 11 then used to prepare diverse urea derivatives 13-18 via Curtius reaction.

Dates and versions

hal-01460366 , version 1 (07-02-2017)

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Abdel-Rahman Farghaly, Sabah Esmail, Ali Abdel-Hafez, Patrice Vanelle, Hussein El-Kashef. New pyrazole derivatives of potential biological activity. ARKIVOC - Online Journal of Organic Chemistry, 2012, Part7, pp.228--241. ⟨10.3998/ark.5550190.0013.715⟩. ⟨hal-01460366⟩
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