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A derivative of ascorbic acid modulates cAMP production

Abstract : We reported, in previous experiments, that AA is a global regulator of cAMP pools. In this study, we demonstrate that K873, an analog of AA we synthesized and presenting antiproliferative properties, has also an impact on cAMP production. However, K873 has no antioxidant activity, at the contrary of AA. It definitively demonstrates that action of AA on the cAMP production is not linked to antioxidant activity. These data suggest that AA, and derivatives of this molecule, could be promising drug acting on biological processes that are under the control of cAMP dependent pathway. (C) 2013 Elsevier Inc. All rights reserved.
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B. Bordignon, S. Mones, F. Rahman, J. Chiron, F. Peiretti, et al.. A derivative of ascorbic acid modulates cAMP production. Biochemical and Biophysical Research Communications, Elsevier, 2013, 439 (1), pp.137--141. ⟨10.1016/j.bbrc.2013.08.004⟩. ⟨hal-01460434⟩



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