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Elaboration of Glycopolymer-Functionalized Micelles from an N-Vinylpyrrolidone/Lactide-Based Reactive Copolymer Platform

Abstract : Glycopolymer-corona-based micelles are obtained in a one-pot procedure, through reaction of D-mannosamine or D-glucosamine with the N-succinimidyl (NS) esters of a poly(D,L-lactide)-block-poly(N-acryloxysuccinimide-co-N-vinylpyrrolidone ) (PLA-b-P(NAS-co-NVP)) amphiphilic copolymer (presenting quasi-alternating NAS/NVP units) in dimethyl sulfoxide (DMSO), followed by nanoprecipitation and dialysis against water. The glycopolymer micelles exhibit a higher CMC and size than those obtained from unmodified copolymer, due to increased hydrophilicity of the external block as a result of sugar derivatization, and the availability of the sugars at the micelle surface is evidenced through interactions with Concanavalin A (Con A) lectin, as attested by turbidimetric measurements and enzyme-linked lectin assay (ELLA). Interestingly, the glycopolymer micelles can be further used for hydrophobic molecule encapsulation and release, as shown with imiquimod, while keeping their interactions with con A intact. It is concluded that the PLA-based amphiphilic/reactive copolymer represents a versatile platform for glycopolymer-based micelle constructs for drug/vaccine delivery.
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https://hal-amu.archives-ouvertes.fr/hal-01460465
Contributor : Didier Gigmes <>
Submitted on : Tuesday, February 7, 2017 - 4:43:24 PM
Last modification on : Thursday, July 9, 2020 - 1:12:02 PM

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Nadege Handke, Vincent Lahaye, Denis Bertin, Thierry Delair, Bernard Verrier, et al.. Elaboration of Glycopolymer-Functionalized Micelles from an N-Vinylpyrrolidone/Lactide-Based Reactive Copolymer Platform. Macromolecular Bioscience, Wiley-VCH Verlag, 2013, 13 (9), pp.1213--1220. ⟨10.1002/mabi.201300102⟩. ⟨hal-01460465⟩

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