New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

Marc Since; Thomas Freret; Gerald Nee; Thierry Terme; Patrice Vanelle; Michel Boulouard

doi:10.1016/j.ejmech.2013.08.041

Journal articles

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

Marc Since ¹ Thomas Freret ² Gerald Nee Thierry Terme ³ Patrice Vanelle ³ Michel Boulouard ²

1 CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie

2 GMPc - Groupe Mémoire et Plasticité comportementale

3 ICR - Institut de Chimie Radicalaire

Abstract : A series of substituted 6-nitrophenylpropanamide derivatives (1-20) were synthesized using either the TDAE strategy or classical organic reactions. All these compounds were characterized by fusion point, 1H NMR,13C NMR, elemental analysis or mass spectrometry data. Because of their structural analogy with recently published compounds possessing antinociceptive properties, our derivatives were screened for peripheral analgesic activities on acetic acid-induced writhing in mice. Compound

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Chemical Sciences

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New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

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New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

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