Journal articles
Synthesis and Biological Evaluation of Methylenecyclopropane Analogues of Nucleosides
Abstract : Starting from a chiral methylenecyclopropane building block, readily obtained by enzymatic desymmetrization of a meso-diol, two types of methylenecyclopropane analogues of nucleosides were synthesized. The first type of nucleosides was obtained from the direct coupling of the chiral building block with 6-chloropurine under Mitsunobu reaction conditions followed by the functionalization of the purine base. The second type of nucleosides featured a Curtius rearrangement as the key step and the uracil heterocycle was then constructed by a linear methodology. These derivatives were evaluated as potential agents against important viral pathogens. None of the new compounds had significant antiviral activity at a concentration of 100 g/mL, which was the highest concentration tested.
https://hal-amu.archives-ouvertes.fr/hal-01460478
Contributor : Didier Gigmes <>
Submitted on : Tuesday, February 7, 2017 - 4:43:58 PM
Last modification on : Thursday, February 21, 2019 - 10:30:02 AM
Contributor : Didier Gigmes <>
Submitted on : Tuesday, February 7, 2017 - 4:43:58 PM
Last modification on : Thursday, February 21, 2019 - 10:30:02 AM
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