Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

Khrystyna Bolibrukh , Svyatoslav Polovkovych , Omar Omar Khoumeri (1) , Tetyana Halenova , Irina Nikolaeva , Olexiy Savchuk , Thierry Terme (1) , Patrice J Vanelle (1) , Vira Lubenets , Volodymyr Novikov

1 ICR - Institut de Chimie Radicalaire

Thiosulfonate derivatives based on quinones were synthesized for studying "structure-activity relationship" compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed.

Domains: Chemical Sciences

Khrystyna Bolibrukh, Svyatoslav Polovkovych, Omar Omar Khoumeri, Tetyana Halenova, Irina Nikolaeva, et al.. Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety. Scientia Pharmaceutica, 2015, 83 (2), pp.221--231. ⟨10.3797/scipharm.1411-14⟩. ⟨hal-01460551⟩