Journal articles
Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis
Pierre-Andre Jarrot
1, 2, 3
Laurent Chiche
4
Baptiste Hervier
5
Vincent Vuiblet
6
Nathalie Bardin
1, 2, 7
Daniel Bertin
8
Benjamin Terrier
9
Zahir Amoura
10
Emmanuel Andrés
11
Eric Rondeau
12
Mohamed Hamidou
13
Laurent Daniel
14
Jean-Loup Pennaforte
15
Philippe Halfon
16
Eric Daugas
17
Bertrand Dussol
18, 2
Xavier Puéchal
19
Gilles Kaplanski
2, 7, 1
Noemie Jourde-Chiche
1, 2, 3
Pierre-Andre Jarrot 1, 2, 3
Author
Laurent Chiche 4
Author
Baptiste Hervier 5
Author
Vincent Vuiblet 6
Author
Nathalie Bardin 1, 2, 7
Author
Daniel Bertin 8
Author
Benjamin Terrier 9
Author
Zahir Amoura 10
Author
Emmanuel Andrés 11
Author
Eric Rondeau 12
Author
Mohamed Hamidou 13
Author
Laurent Daniel 14
Author Employer institution : Université de Bretagne Sud IdHAL : laurent-daniel
Jean-Loup Pennaforte 15
Author
Philippe Halfon 16
Author
Eric Daugas 17
Author
Bertrand Dussol 18, 2
Author
1
Physiopathologie de l'Endothelium (Faculte de Pharmacie 27, Boulevard Jean Moulin 13385 Marseille cedex 05 - France)
- VRCM - Vascular research center of Marseille (Faculté de Pharmacie, 27 bd Jean Moulin 13385 Marseille Cedex 5 - France)
- AMU - Aix Marseille Université : UMR S1076 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1076 (101, rue de Tolbiac, 75013 Paris - France)
2
VRCM - Vascular research center of Marseille (Faculté de Pharmacie, 27 bd Jean Moulin 13385 Marseille Cedex 5 - France)
- AMU - Aix Marseille Université : UMR S1076 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1076 (101, rue de Tolbiac, 75013 Paris - France)
3
LA CONCEPTION - Hôpital de la Conception [CHU - APHM] (147 Boulevard Baille 13005 Marseille - France)
4
CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7280 (France)
- AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
5
Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière] (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
6
MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369 (Faculté de Médecine 51 Rue Cognacq-Jay 51095 REIMS CEDEX - France)
- URCA - Université de Reims Champagne-Ardenne : UMR 7369 (2 avenue Robert Schuman, 51100 Reims. - France)
- SFR CAP Santé (Champagne-Ardenne Picardie Santé) (Faculté de Médecine de Reims, 51, rue Cognacq Jay, CS 30018,
51095 Reims Cedex - France)
- URCA - Université de Reims Champagne-Ardenne : FED 4231 (2 avenue Robert Schuman, 51100 Reims. - France)
- UPJV - Université de Picardie Jules Verne : FED 4231 (Chemin du Thil - 80000 Amiens - France)
- CNRS - Centre National de la Recherche Scientifique : UMR 7369 (France)
7
Laboratoire d'Immunologie [Hôpital de la Conception - APHM] (147, boulevard Baille
13385 Marseille cedex 05 - France)
- APHM - Assistance Publique - Hôpitaux de Marseille (Direction générale AP-HM 80, rue Brochier 13 354 Marseille Cedex 5 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
- LA CONCEPTION - Hôpital de la Conception [CHU - APHM] (147 Boulevard Baille 13005 Marseille - France)
- CNRS - Centre National de la Recherche Scientifique (France)
8
AMU - Aix Marseille Université (Aix-Marseille Université
Jardins du Pharo
58 Boulevard Charles Livon
13284 Marseille cedex 7 - France)
9
Service de Médecine Interne (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Hôpital Cochin [AP-HP] (27 Rue du Faubourg Saint-Jacques 75014 Paris - France)
- UPD5 - Université Paris Descartes - Paris 5 (12, rue de l'École de Médecine - 75270 Paris cedex 06 - France)
10
Service de médecine interne [CHU Pitié-Salpétrière] (47-83, boulevard de l'Hôpital 75651 PARIS Cedex 13 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
11
Hôpital Civil de Strasbourg (1 place de l'hôpital, 67000 Strasbourg, France - France)
- Hôpital Civil de Strasbourg (France)
12
Urgences néphrologiques et transplantation rénale [CHU Tenon] (4 rue de la Chine, Paris, 75020 - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Tenon [APHP] (4 Rue de la Chine, 75020 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- Sorbonne Université (France)
13
CHU Nantes - Centre hospitalier universitaire de Nantes (1 Place Alexis-Ricordeau, 44000 Nantes - France)
14
HCTI - Héritages et Constructions dans le Texte et l'Image (20 rue Duquesne 29238 Brest Cedex 03 - France)
- UBS - Université de Bretagne Sud (BP 92116 - 56321 Lorient cedex - France)
- UBO - Université de Brest : EA4249 (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
- IBSHS - Institut Brestois des Sciences de l'Homme et de la Société (20 rue Duquesne, CS 93837 29238 Brest Cedex 3 - France)
- UBO - Université de Brest (Université de Bretagne Occidentale - 3 Rue des Archives 29238, Brest - France)
15
Service de Médecine Interne (Reims - France)
- Hôpital Robert Debré (France)
- CHU Reims - Centre Hospitalier Universitaire de Reims (45, rue Cognacq-Jay 51100 Reims - France)
16
Hôpital Européen [Fondation Ambroise Paré - Marseille] (6 rue Désirée Clary
13003 Marseille - France)
17
Hôpital Bichat - Claude Bernard (46, rue Henri-Huchard 75018 Paris - France)
18
Chirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM] (Hôpital de la Conception
147, boulevard Baille
13005
Marseille
- France)
- AMU - Aix Marseille Université (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- APHM - Assistance Publique - Hôpitaux de Marseille (Direction générale AP-HM 80, rue Brochier 13 354 Marseille Cedex 5 - France)
- LA CONCEPTION - Hôpital de la Conception [CHU - APHM] (147 Boulevard Baille 13005 Marseille - France)
19
Hôpital Cochin [AP-HP] (27 Rue du Faubourg Saint-Jacques 75014 Paris - France)
Abstract : The aim of the study was to report the clinical, biological, and pathological characteristics of patients with glomerulonephritis (GN) secondary to systemic lupus erythematosus (SLE)/antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) overlap syndrome.A nationwide survey was conducted to identify cases of SLE/AAV overlap syndrome. Data were collected from SLE and AAV French research groups. Inclusion criteria were diagnosis of both SLE and AAV according to international classification criteria and biopsy-proven GN between 1995 and 2014. Additional cases were identified through a systematic literature review. A cohort of consecutive biopsy-proven GN was used to study the prevalence of overlapping antibodies and/or overlap syndrome.The national survey identified 8 cases of SLE/AAV overlap syndrome. All patients were female; median age was 40 years. AAV occurred before SLE (n = 3), after (n = 3), or concomitantly (n = 2). Six patients had rapidly progressive GN and 3/8 had alveolar hemorrhage. All patients had antinuclear antibodies (ANA); 7/8 had p-ANCA antimyeloperoxidase (MPO) antibodies. Renal biopsies showed lupus nephritis (LN) or pauci-immune GN. Remission was obtained in 4/8 patients. A literature review identified 31 additional cases with a similarly severe presentation. In the GN cohort, ANCA positivity was found in 30% of LN, ANA positivity in 52% of pauci-immune GN, with no correlation with pathological findings. The estimated prevalence for SLE/AAV overlap syndrome was 2/101 (2%).In patients with GN, SLE/AAV overlap syndrome may occur but with a low prevalence. Most patients have an aggressive renal presentation, with usually both ANA and anti-MPO antibodies. Further studies are needed to assess shared pathogenesis and therapeutic options.
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https://hal-amu.archives-ouvertes.fr/hal-01460623
Contributor : Françoise Dignat-George <>
Submitted on : Tuesday, February 7, 2017 - 5:26:31 PM
Last modification on : Wednesday, May 26, 2021 - 7:56:02 PM
Contributor : Françoise Dignat-George <>
Submitted on : Tuesday, February 7, 2017 - 5:26:31 PM
Last modification on : Wednesday, May 26, 2021 - 7:56:02 PM
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- HAL Id : hal-01460623, version 1
- DOI : 10.1097/MD.0000000000003748
- PUBMED : 27258503
Collections
UNIV-AMU | CNRS | UNIV-PARIS5 | UNIV-BREST | USPC | HCTI | URCA | HCTI_UBS | UBS | MEDYC | CAPSANTE | IBSHS | UNIV-PARIS | SORBONNE-UNIVERSITE | SU-TI
Citation
Pierre-Andre Jarrot, Laurent Chiche, Baptiste Hervier, Vincent Vuiblet, Nathalie Bardin, et al.. Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Overlap Syndrome in Patients With Biopsy-Proven Glomerulonephritis. Medicine, Lippincott, Williams & Wilkins, 2016, 95, pp.e3748. ⟨10.1097/MD.0000000000003748⟩. ⟨hal-01460623⟩
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