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Original synthesis of benzo[f]indole-4,9-dione derivatives using TDAE strategy

Abstract : A new series of 1-methyl-1H-benzo[f]indole-4,9-dione derivatives was prepared via a one-pot 'Sonogashira-Cyclization' reaction with propagylic alcohol in the presence of a palladium catalyst leading to regio-isomers of 2- and 3-(chloromethyl)-1-methyl-1H-benzo[f]indole-4,9-dione after chlorination. The reaction of the 2- and 3-(chloromethyl)-1-methyl-1H-benzo[f]indole-4,9-dione derivatives with various aldehydes and N-sulfonimides in the presence of TDAE under mild conditions led to the corresponding alcohols and N-sulfonamide derivatives in good yield. (C) 2015 Elsevier Ltd. All rights reserved.
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Submitted on : Tuesday, February 7, 2017 - 5:36:22 PM
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Aida R. Nadji-Boukrouche, Sopheak On, Omar Khoumeri, Thierry Terme, Patrice Vanelle. Original synthesis of benzo[f]indole-4,9-dione derivatives using TDAE strategy. Tetrahedron Letters, Elsevier, 2015, 56 (17), pp.2272--2275. ⟨10.1016/j.tetlet.2015.03.074⟩. ⟨hal-01460642⟩

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