HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers

Abstract : A simplified strategy for preparing non-natural information-containing polymers is reported. The concept relies on the successive ligation of oligomers that contain minimal sequence motifs. It was applied here to the synthesis of digitally-encoded poly(triazole amide)s, in which propyl and 2-methyl propyl motifs are used to code 0 and 1, respectively. A library of four oligo(triazole amide)s containing the information dyads 00, 01, 10, and 11 was prepared. These oligomers contain two reactive functions, that is, an alkyne and a carboxylic acid. Thus, they can be linked to another with the help of a reactive spacer containing azide and amine functions. Using two successive chemoselective steps, that is, azide-alkyne Huisgen cycloaddition and carboxylic acid-amine coupling, monodisperse polymers can be obtained. In particular, the library of dyads permits the implementation of any desired sequence using a small number of steps. As a proof-of-concept, the synthesis of molecular bytes 00000000 and 00000110 is described.
Document type :
Journal articles
Complete list of metadata

Contributor : Didier Gigmes Connect in order to contact the contributor
Submitted on : Tuesday, February 7, 2017 - 5:36:40 PM
Last modification on : Tuesday, December 14, 2021 - 8:42:06 AM

Links full text




Thanh Tam Trinh, Laurence Oswald, Delphine Chan-Seng, Laurence Charles, Jean-François Lutz. Preparation of Information-Containing Macromolecules by Ligation of Dyad-Encoded Oligomers. Chemistry - A European Journal, Wiley-VCH Verlag, 2015, 21 (34), pp.11961--11965. ⟨10.1002/chem.201502414⟩. ⟨hal-01460650⟩



Record views