Skip to Main content Skip to Navigation
Journal articles

Prenatal ischemia deteriorates white matter, brain organization, and function: implications for prematurity and cerebral palsy

Abstract : Cerebral palsy (CP) describes a group of neurodevelopmental disorders of posture and movement that are frequently associated with sensory, behavioral, and cognitive impairments. The clinical picture of CP has changed with improved neonatal care over the past few decades, resulting in higher survival rates of infants born very preterm. Children born preterm seem particularly vulnerable to perinatal hypoxia-ischemia insults at birth. Animal models of CP are crucial for elucidating underlying mechanisms and for development of strategies of neuroprotection and remediation. Most animal models of CP are based on hypoxia-ischemia around the time of birth. In this review, we focus on alterations of brain organization and functions, especially sensorimotor changes, induced by prenatal ischemia in rodents and rabbits, and relate these alterations to neurodevelopmental disorders found in preterm children. We also discuss recent literature that addresses the relationship between neural and myelin plasticity, as well as possible contributions of white matter injury to the emergence of brain dysfunctions induced by prenatal ischemia.
Complete list of metadatas

Cited literature [52 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-01461927
Contributor : Jacques-Olivier Coq <>
Submitted on : Monday, February 13, 2017 - 7:05:14 PM
Last modification on : Monday, July 20, 2020 - 12:34:51 PM
Long-term archiving on: : Sunday, May 14, 2017 - 12:28:52 PM

File

Coq_2016_author_version.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Jacques-Olivier Coq, Maxime Delcour, Vicky Massicotte, Olivier Baud, Mary Barbe. Prenatal ischemia deteriorates white matter, brain organization, and function: implications for prematurity and cerebral palsy. Developmental Medicine and Child Neurology, Wiley-Blackwell, 2016, 58 (S4), pp.7-11. ⟨10.1111/dmcn.13040⟩. ⟨hal-01461927⟩

Share

Metrics

Record views

401

Files downloads

640