Skip to Main content Skip to Navigation
Journal articles

Understanding the role of miR-33 in brain lipid metabolism: implications for Alzheimer's disease

Abstract : Because of its incidence and devastating consequences, Alzheimer’s disease (AD) has attracted much research attention in the last decades. Intensive work led to the identification of a number of cellular and molecular pathophysiologic mechanisms including Tau alterations, β-amyloid deposition, lipid homeostasis dysregulation, excitotoxicity, neuroinflammation or autophagy defects (Di Paolo and Kim, 2011; Ittner and Gotz, 2011; Heppner et al., 2015; Menzies et al., 2015; Wang and Mandelkow, 2015). Despite of the efforts, how these different pathways interact and contribute to disease pathogenesis remains poorly understood. Nonetheless, the presence of Aβ plaques, formed by the sequential cleavage of the amyloid precursor protein (APP), is a prominent neuropathologic feature of the disease and is still thought to be central to AD development (Nhan et al., 2015).
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-01464467
Contributor : Eduardo Gascon <>
Submitted on : Wednesday, February 15, 2017 - 2:02:55 PM
Last modification on : Wednesday, October 14, 2020 - 3:50:36 AM
Long-term archiving on: : Tuesday, May 16, 2017 - 12:11:01 PM

Files

JN-JC-4571-15_R2.pdf
Files produced by the author(s)

Identifiers

Collections

UNIV-AMU | CNRS | INT | CDF | PSL

Citation

Florence Jaouen, Eduardo Gascon. Understanding the role of miR-33 in brain lipid metabolism: implications for Alzheimer's disease. Journal of Neuroscience, Society for Neuroscience, 2016, 36 (9), pp.2558-2560. ⟨10.1523/JNEUROSCI.4571-15.2016⟩. ⟨hal-01464467⟩

Share

Metrics

Record views

214

Files downloads

379