D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2016

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

Ahmet Dogan
  • Fonction : Auteur
Oleg Kovrov
  • Fonction : Auteur
Monica Stoppini
  • Fonction : Auteur
Gilles Grateau
  • Fonction : Auteur

Résumé

Apolipoprotein C-III deficiency provides cardiovascular protection, but apolipoprotein C-III is not known to be associated with human amyloidosis. Here we report a form of amyloidosis characterized by renal insufficiency caused by a new apolipoprotein C-III variant, D25V. Despite their uremic state, the D25V-carriers exhibit low triglyceride (TG) and apolipoprotein C-III levels, and low very-low-density lipoprotein (VLDL)/high high-density lipoprotein (HDL) profile. Amyloid fibrils comprise the D25V-variant only, showing that wild-type apolipoprotein C-III does not contribute to amyloid deposition in vivo. The mutation profoundly impacts helical structure stability of D25V-variant, which is remarkably fibrillogenic under physiological conditions in vitro producing typical amyloid fibrils in its lipid-free form. D25V apolipoprotein C-III is a new human amyloidogenic protein and the first conferring cardioprotection even in the unfavourable context of renal failure, extending the evidence for an important cardiovascular protective role of apolipoprotein C-III deficiency. Thus, fibrate therapy, which reduces hepatic APOC3 transcription, may delay amyloid deposition in affected patients.
Fichier principal
Vignette du fichier
ncomms10353.pdf (2.63 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01467259 , version 1 (09-06-2021)

Licence

Paternité

Identifiants

Citer

Sophie Valleix, Guglielmo Verona, Noemie Jourde-Chiche, Brigitte Nédelec, P Patrizia Mangione, et al.. D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile. Nature Communications, 2016, pp.10353. ⟨10.1038/ncomms10353⟩. ⟨hal-01467259⟩
248 Consultations
62 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More