Skip to Main content Skip to Navigation
Journal articles

Deciphering the molecular mechanisms of anti-tubulin plant derived drugs

Abstract : Even though commercialized anticancer drugs are now produced by pharmaceutical companies, most of them were originally obtained from natural sources, and more particularly from plants. Indeed, many structurally diverse compounds isolated from plants or marine flora have been purified and synthesized for their anticancer bioactivity. Among these, several molecules belong to the class of anticancer drugs which target the microtubule cytoskeleton, either by stabilizing it or destabilizing it. To characterize the activity of these drugs and to understand in which physiological context they are more likely to be used as therapeutic agents, it is necessary to fully determine their interaction with tubulin. Understanding the molecular basis of their effects on microtubule cytoskeleton is an important step in designing analogs with greater pharmacological activity and with fewer side effects. In addition, knowing the molecular mechanism of action of each drug that is already used in chemotherapy protocols will also help to find strategies to circumvent resistance. By taking examples of known anti-tubulin plant derived drugs, we show how identification of microtubule targeting agents and further characterization of their activity can be achieved combining biophysical and biochemical approaches. We also illustrate how continuing in depth study of molecules with already known primary mechanisms of action can lead to the discovery of new targets or biomarkers which can open new perspectives in anticancer strategies.
Complete list of metadata

Cited literature [66 references]  Display  Hide  Download
Contributor : François Devred Connect in order to contact the contributor
Submitted on : Friday, February 24, 2017 - 10:07:37 AM
Last modification on : Thursday, October 21, 2021 - 4:00:56 AM
Long-term archiving on: : Thursday, May 25, 2017 - 12:22:11 PM


16 Phytochemistry Reviews 2014...
Explicit agreement for this submission




Pascale Barbier, Philipp O. Tsvetkov, Gilles Breuzard, François Devred. Deciphering the molecular mechanisms of anti-tubulin plant derived drugs. Phytochemistry Reviews, Springer Verlag, 2014, 13 (1), pp.157-169. ⟨10.1007/s11101-013-9302-8⟩. ⟨hal-01470519⟩



Record views


Files downloads