Global cancer statistics, 2012, Jemal, A. Global cancer statistics, pp.87-108, 2012. ,
DOI : 10.1002/ijc.29210
Brain metastases. Histology, multiplicity, surgery, and survival, Cancer Epidemiology of brain metastases. Cancer Radiother. 2015, vol.78, issue.19, pp.1781-1788, 1996. ,
Intracerebral metastases in solid-tumor patients: Natural history and results of treatment, Cancer, vol.80, issue.2, pp.384-394, 1981. ,
DOI : 10.1002/1097-0142(19810715)48:2<384::AID-CNCR2820480227>3.0.CO;2-8
Stereotactic radiosurgery for brain metastasis in non-small cell lung cancer, Radiation Oncology Journal, vol.33, issue.3, pp.207-216, 2015. ,
DOI : 10.3857/roj.2015.33.3.207
Bevacizumab in Patients with Nonsquamous Non-Small Cell Lung Cancer and Asymptomatic, Untreated Brain Metastases (BRAIN): A Nonrandomized, Phase II Study Hallmarks of cancer: The next generation, Clin. Cancer Res. Cell, vol.2015, issue.144, pp.1896-1903, 2011. ,
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial, The Lancet Oncology, vol.13, issue.3, pp.239-246, 2012. ,
DOI : 10.1016/S1470-2045(11)70393-X
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma, N. Engl. J. Med, vol.361, pp.947-957, 2009. ,
Mutations, Journal of Clinical Oncology, vol.31, issue.27, pp.31-3327, 2013. ,
DOI : 10.1200/JCO.2012.44.2806
-Positive Lung Cancer, New England Journal of Medicine, vol.368, issue.25, pp.2385-2394, 2013. ,
DOI : 10.1056/NEJMoa1214886
URL : https://hal.archives-ouvertes.fr/in2p3-00451031
-Rearranged Non???Small-Cell Lung Cancer and Brain Metastases, Journal of Clinical Oncology, vol.33, issue.17, pp.1881-1888, 2015. ,
DOI : 10.1200/JCO.2014.59.0539
URL : https://hal.archives-ouvertes.fr/in2p3-00451031
First-Line Afatinib versus Chemotherapy in Patients with Non???Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases, Journal of Thoracic Oncology, vol.11, issue.3, pp.380-390, 2016. ,
DOI : 10.1016/j.jtho.2015.11.014
-Rearranged Non???Small-Cell Lung Cancer Previously Treated With Chemotherapy and Crizotinib: Results From ASCEND-2, Journal of Clinical Oncology, vol.34, issue.24, pp.2866-2873, 2016. ,
DOI : 10.1200/JCO.2015.65.5936
The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses, Clinical Cancer Research, vol.13, issue.6, pp.1663-1674, 2007. ,
DOI : 10.1158/1078-0432.CCR-06-2854
Blood???brain Barrier Remodeling during Brain Metastasis Formation, Molecular Medicine, vol.22, issue.1, pp.32-40, 2016. ,
DOI : 10.2119/molmed.2015.00207
Differential expression of biomarkers in primary non-small cell lung cancer and metastatic sites, J. Thorac. Oncol, vol.4, pp.1212-1220, 2009. ,
The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives, The Journal of Medical Investigation, vol.61, issue.3.4, pp.241-253 ,
DOI : 10.2152/jmi.61.241
The role of RAS oncogene in survival of patients with lung cancer: A systematic review of the literature with meta-analysis, Br. J. Cancer, vol.92, pp.131-139, 2005. ,
KRAS Mutations in Lung Adenocarcinoma: Molecular and Epidemiological Characteristics, Methods for Detection, and Therapeutic Strategy Perspectives, Current Molecular Medicine, vol.15, issue.5, pp.418-432, 2015. ,
DOI : 10.2174/1566524015666150505161412
Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer in the Real-World Setting in Central Europe, Journal of Thoracic Oncology, vol.10, issue.9, pp.1370-1374, 2015. ,
DOI : 10.1097/JTO.0000000000000621
EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas, Journal of Thoracic Oncology, vol.9, issue.2, pp.195-199 ,
DOI : 10.1097/JTO.0000000000000069
EGFR mutations are associated with higher incidence of distant metastases and smaller tumor size in patients with non-small-cell lung cancer based on PET/CT scan, Medical Oncology, vol.1, issue.5, 2016. ,
DOI : 10.1007/s12032-015-0714-8
Epidermal growth factor receptor mutation and pattern of brain metastasis in patients with non-small cell lung cancer, The Korean Journal of Internal Medicine, p.20, 2016. ,
DOI : 10.3904/kjim.2015.158
Specific KRAS amino acid substitutions and EGFR mutations predict site-specific recurrence and metastasis following non-small-cell lung cancer surgery, British Journal of Cancer, vol.7, issue.3, pp.346-353, 2016. ,
DOI : 10.1371/journal.pone.0106053
EGFR mutated non-small cell lung cancer patients: More prone to development of bone and brain metastases?, Lung Cancer, vol.84, issue.1, pp.86-91, 2014. ,
DOI : 10.1016/j.lungcan.2014.01.006
Serum Biomarkers Associated with Clinical Outcomes Fail to Predict Brain Metastases in Patients with Stage IV Non-Small Cell Lung Cancers, PLOS ONE, vol.14, issue.19, 2016. ,
DOI : 10.1371/journal.pone.0146063.t004
The correlation between EGFR mutation status and the risk of brain metastasis in patients with lung adenocarcinoma, Journal of Neuro-Oncology, vol.82, issue.2, pp.79-85, 2015. ,
DOI : 10.1007/s11060-015-1776-3
Different EGFR Gene Mutations in Exon 18, 19 and 21 as Prognostic and Predictive Markers in NSCLC: A Single Institution Analysis, Molecular Diagnosis & Therapy, vol.14, issue.16, pp.55-63, 2016. ,
DOI : 10.1007/s40291-015-0176-x
Survival but not brain metastasis response relates to lung cancer mutation status after radiosurgery, Journal of Neuro-Oncology, vol.77, issue.3, pp.483-491, 2016. ,
DOI : 10.1007/s11060-015-1986-8
Exon 19 deletion of epidermal growth factor receptor is associated with prolonged survival in brain metastases from non-small-cell lung cancer, Tumor Biology, vol.15, issue.15, pp.9251-9258, 2015. ,
DOI : 10.1007/s13277-015-3653-2
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer, Molecular Cancer, vol.11, issue.1, p.73, 2012. ,
DOI : 10.1038/sj.bjc.6690178
Identifying activating mutations in the EGFR gene: prognostic and therapeutic implications in non-small cell lung cancer, Jornal Brasileiro de Pneumologia, vol.41, issue.4, pp.365-375, 2015. ,
DOI : 10.1590/S1806-37132015000004531
Meta-analysis of Epidermal Growth Factor Receptor and KRAS Gene Status between Primary and Corresponding Metastatic Tumours of Non-small Cell Lung Cancer, Clinical Oncology, vol.27, issue.1, pp.30-39, 2015. ,
DOI : 10.1016/j.clon.2014.09.014
Preclinical Comparison of Osimertinib with Other EGFR-TKIs in EGFR-Mutant NSCLC Brain Metastases Models, and Early Evidence of Clinical Brain Metastases Activity, Clinical Cancer Research, vol.22, issue.20, pp.5130-5140, 2016. ,
DOI : 10.1158/1078-0432.CCR-16-0399
Insights into brain metastasis in patients with ALK + lung cancer: Is the brain truly a sanctuary? Cancer Metastasis Rev, pp.797-805, 2015. ,
The IASLC Lung Cancer Staging Project: Proposals for the Revision of the TNM Stage Groupings in the Forthcoming (Seventh) Edition of the TNM Classification of Malignant Tumours, Journal of Thoracic Oncology, vol.2, issue.8, pp.706-714, 2007. ,
DOI : 10.1097/JTO.0b013e31812f3c1a
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1), European Journal of Cancer, vol.45, issue.2, pp.228-247, 2009. ,
DOI : 10.1016/j.ejca.2008.10.026
Lack of EGFR-activating mutations in European patients with triple-negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles, Breast Cancer Research, vol.17, issue.6, p.133, 2011. ,
DOI : 10.1158/1078-0432.CCR-10-2185
Systemic Therapy for Stage IV Non???Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update, Journal of Clinical Oncology, vol.33, issue.30, pp.3488-3515, 2015. ,
DOI : 10.1200/JCO.2015.62.1342
Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Annals of Oncology, vol.25, issue.suppl 3, pp.27-39, 2014. ,
DOI : 10.1093/annonc/mdu199
EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force, European Journal of Neurology, vol.6, issue.7, pp.674-681, 2006. ,
DOI : 10.1093/annonc/mdh276
Recommandations de l???Anocef pour la prise en charge des m??tastases c??r??brales, Cancer/Radioth??rapie, vol.19, issue.1, pp.66-71 ,
DOI : 10.1016/j.canrad.2014.11.006