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Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice

Abstract : Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-(A), have been reported to inhibit zinc-induced dimerization of the A metal-binding domain and slow A aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.
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Submitted on : Tuesday, February 28, 2017 - 12:06:15 PM
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Philipp Tsvetkov, Ivan Cheglakov, Armen Ovsepyan, Oleg Mediannikov, Alexander Morozov, et al.. Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice. Journal of Alzheimer's Disease, IOS Press, 2016, pp.20 - 20. ⟨10.3233/JAD-150031⟩. ⟨hal-01478712⟩

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