Journal articles
Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice
Abstract : Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-(A), have been reported to inhibit zinc-induced dimerization of the A metal-binding domain and slow A aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.
https://hal-amu.archives-ouvertes.fr/hal-01478712
Contributor : François Devred Connect in order to contact the contributor
Submitted on : Tuesday, February 28, 2017 - 12:06:15 PM
Last modification on : Tuesday, July 14, 2020 - 11:04:07 AM
Long-term archiving on: : Monday, May 29, 2017 - 1:37:21 PM
Contributor : François Devred Connect in order to contact the contributor
Submitted on : Tuesday, February 28, 2017 - 12:06:15 PM
Last modification on : Tuesday, July 14, 2020 - 11:04:07 AM
Long-term archiving on: : Monday, May 29, 2017 - 1:37:21 PM
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JAD150031(1).pdf
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