Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice

Philipp A Tsvetkov (1, 2) , Ivan B Cheglakov (3) , Armen A Ovsepyan (3) , Oleg O Mediannikov (4) , Alexander A Morozov (4) , Georgy B Telegin (3) , Sergey A Kozin (4)

1 Institute of General Pathology and Pathophysiology
2 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
3 IBCh RAS - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry
4 Kimonella Ventures Ltd.

Two tetrapeptides, HAEE and RADD, which are ionic-complementary to the primary zinc recognition site of amyloid-(A), have been reported to inhibit zinc-induced dimerization of the A metal-binding domain and slow A aggregation in vitro. In the present study, we investigate the impact of HAEE and RADD on the development of cerebral-amyloidosis in a mouse model of Alzheimer's disease. We have found chronic intravenous administration of each peptide results in significant decrease of amyloid plaque burden in the treated mice.

Mots clés: Alzheimer's disease; amyloid- β; mouse models; protein aggregation in vivo

Domaines: Cancer; Neurobiologie; Biophysique

Philipp A Tsvetkov, Ivan B Cheglakov, Armen A Ovsepyan, Oleg O Mediannikov, Alexander A Morozov, et al.. Peripherally Applied Synthetic Tetrapeptides HAEE and RADD Slow Down the Development of Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice. Journal of Alzheimer's Disease, 2016, pp.20 - 20. ⟨10.3233/JAD-150031⟩. ⟨hal-01478712⟩