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Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling

Abstract : Clear cell ependymoma is one of the 4 main histological subtypes of ependymomas defined by the World Health Organization (WHO) classification of tumors of the CNS. DNA methylation profiling can distinguish 4 subgroups of intracranial ependymomas, including supratentorial (ST) ependymomas with Yes-associated protein 1 fusion (YAP1), ST ependymomas with fusion of v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), posterior fossa ependymomas with balanced genome, and posterior fossa ependymomas with chromosomal instability. In addition, trisomy 19 is a genomic hallmark of ependymomas with rich branching capillaries. However, the relation of histological and molecular subtypes is unclear.
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Submitted on : Monday, March 20, 2017 - 10:25:26 AM
Last modification on : Tuesday, March 15, 2022 - 3:31:21 AM
Long-term archiving on: : Wednesday, June 21, 2017 - 12:12:11 PM

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Dominique Figarella-Branger, E Le Lechapt-Zalcman, E Tabouret, Stephanie Jünger, André Maues de Paula, et al.. Supratentorial clear cell ependymomas with branching capillaries demonstrate characteristic clinicopathological features and pathological activation of nuclear factor-kappaB signaling. Neuro-Oncology, Oxford University Press (OUP), 2016, 18, pp.919-927. ⟨10.1093/neuonc/now025⟩. ⟨hal-01478840⟩

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