Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.

C Mazouni (1) , F Fina (2) , S Romain (2) , P Bonnier (3) , L Ouafik (2) , P-M Martin (2)

1 IGR - Institut Gustave Roussy
2 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]
3 CHPB - Centre Hospitalier Privé Beauregard.

PURPOSE: To develop a prognostic nomogram to predict freedom from recurrence for patients treated with adjuvant hormonal therapy (HT) for localised breast cancer (BC). METHODS: We performed a retrospective analysis of 142 patients treated with adjuvant HT between 1996 and 2000. Clinical and pathological parameters were analysed. RESULTS: A nomogram that predicts the probability of remaining free of recurrence for 5 years after surgery with adjuvant HT was developed using a Cox proportional hazards regression model. The progesterone receptor status (p < 0.001), nodal status (p = 0.008) and cathepsin-D (p < 0.001) were retained to construct the nomogram (C-index 0.734). CONCLUSIONS: The nomogram we developed may be useful for estimating the probability of successful treatment 5 years after surgery for localised BC.

Domaines: Cancer

C Mazouni, F Fina, S Romain, P Bonnier, L Ouafik, et al.. Post-operative nomogram for predicting freedom from recurrence after surgery in localised breast cancer receiving adjuvant hormone therapy.. Journal of Cancer Research and Clinical Oncology, 2015, 141 (6), pp.1083-1088. ⟨10.1007/s00432-014-1889-7⟩. ⟨hal-01480127⟩