M. Akrim, M. Bally, G. Ball, J. Tommassen, H. Teerink et al., Xcp-mediated protein secretion in Pseudomonas aeruginosa: identification of two additional genes and evidence for regulation of xcp gene expression, Molecular Microbiology, vol.33, issue.Suppl., pp.431-443, 1993.
DOI : 10.1016/0378-1119(85)90120-9

D. N. Arvidson, P. Youderian, T. D. Schneider, and G. D. Stormo, Automated kinetic assay of -galactosidase activity, Biotechniques, vol.6, pp.733-736, 1991.

M. Bally, A. Filloux, M. Akrim, G. Ball, A. Lazdunski et al., Protein secretion in Pseudomonas aeruginosa: characterization of seven xcp genes and processing of secretory apparatus components by prepilin peptidase, Molecular Microbiology, vol.158, issue.9, pp.1121-1131, 1992.
DOI : 10.1016/0378-1119(85)90120-9

M. J. Bjorn, P. A. Sokol, and B. H. Iglewski, Influence of iron on yields of extracellular products in Pseudomonas aeruginosa cultures, J Bacteriol, vol.138, pp.193-200, 1979.

J. M. Brint and D. E. Ohman, Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family., Journal of Bacteriology, vol.177, issue.24, pp.7155-7153, 1995.
DOI : 10.1128/jb.177.24.7155-7163.1995

M. J. Brumlik and D. G. Storey, Zinc and iron regulate translation of the gene encoding Pseudomonas aeruginosa elastase, Molecular Microbiology, vol.36, issue.3, pp.337-344, 1992.
DOI : 10.1016/0167-4838(89)90048-4

C. Chen, N. A. Buchmeier, S. Libby, F. C. Fang, M. Krause et al., Central regulatory role for the RpoS sigma factor in expression of Salmonella dublin plasmid virulence genes., Journal of Bacteriology, vol.177, issue.18, pp.5303-5309, 1995.
DOI : 10.1128/jb.177.18.5303-5309.1995

S. H. Choi and E. P. Greenberg, Genetic dissection of DNA binding and luminescence gene activation by the Vibrio fischeri LuxR protein., Journal of Bacteriology, vol.174, issue.12, pp.4064-4069, 1992.
DOI : 10.1128/jb.174.12.4064-4069.1992

D. H. Figurski and D. R. Helinski, Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans, Proceedings of the National Academy of Sciences, vol.76, issue.4, pp.1648-1652, 1979.
DOI : 10.1073/pnas.76.4.1648

A. Filloux, M. Bally, G. Ball, M. Akrim, J. Tommassen et al., Protein secretion in Gram-negative bacteria: transport across the outer membrane involves common mechanisms in different bacteria, EMBO J, vol.9, pp.4323-4329, 1990.

W. C. Fuqua, S. C. Winans, and E. P. Greenberg, Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators., Journal of Bacteriology, vol.176, issue.2, pp.269-275, 1994.
DOI : 10.1128/jb.176.2.269-275.1994

M. J. Gambello, S. Kaye, and B. H. Iglewski, LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr ) and an enhancer of exotoxin A expression, Infect Immun, vol.61, pp.1180-1184, 1993.

S. P. Howard, J. Critch, and A. Bedi, Isolation and analysis of eight exe genes and their involvement in extracellular protein secretion and outer membrane assembly in Aeromonas hydrophila., Journal of Bacteriology, vol.175, issue.20, pp.6695-6703, 1993.
DOI : 10.1128/jb.175.20.6695-6703.1993

S. Jones, B. Yu, N. J. Bainton, M. Birdsall, B. W. Bycroft et al., The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa, EMBO J, vol.12, pp.2477-2482, 1993.

R. Lange and R. Hengge-aronis, Growth phase-regulated expression of bolA and morphology of stationary-phase Escherichia coli cells are controlled by the novel sigma factor sigma S., Journal of Bacteriology, vol.173, issue.14, pp.4474-4481, 1991.
DOI : 10.1128/jb.173.14.4474-4481.1991

A. Latifi, K. M. Winson, M. Foglino, B. W. Bycroft, G. S. Stewart et al., Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1, Molecular Microbiology, vol.17, issue.2, pp.333-344, 1995.
DOI : 10.1111/j.1365-2958.1995.mmi_17020333.x

A. Latifi, M. Foglino, K. Tanaka, P. Williams, and A. Lazdunski, A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhlR (VsmR) to expression of the stationary-phase sigma factor RpoS, Molecular Microbiology, vol.21, issue.6, pp.1137-1146, 1996.
DOI : 10.1046/j.1365-2958.1996.00063.x

P. V. Liu, Extracellular Toxins of Pseudomonas aeruginosa, Journal of Infectious Diseases, vol.130, issue.Supplement, pp.94-99, 1974.
DOI : 10.1093/infdis/130.Supplement.S94

S. Lory, P. C. Tai, D. , and B. D. , Mechanism of protein excretion Gram-negative bacteria: Pseudomonas aeruginosa exotoxin A, J Bacteriol, vol.156, pp.695-702, 1983.

T. Maniatis, E. F. Fritsch, and J. Sambrook, Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, 1982.

E. A. Meighen, Molecular biology of bacterial bioluminescence, Microbiol Rev, vol.55, pp.123-142, 1991.

J. J. Mekalanos, Environmental signals controlling expression of virulence determinants in bacteria., Journal of Bacteriology, vol.174, issue.1, pp.1-7, 1992.
DOI : 10.1128/jb.174.1.1-7.1992

J. N. Miller, Experiments in Molecular Genetics, Blackwell Science Ltd Molecular Microbiology, vol.24, pp.1169-1178, 1972.

U. A. Ochsner and J. Reiser, Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa., Proceedings of the National Academy of Sciences, vol.92, issue.14, pp.6424-6428, 1995.
DOI : 10.1073/pnas.92.14.6424

L. J. Overbye, M. Sandkvist, and M. Bagdasarian, Genes required for extracellular secretion of enterotoxin are clustered in Vibrio cholerae, Gene, vol.132, issue.1, pp.101-106, 1993.
DOI : 10.1016/0378-1119(93)90520-D

L. Passador, J. M. Cook, M. J. Gambello, L. Rust, and B. H. Iglewski, Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication, Science, vol.260, issue.5111, pp.1127-1130, 1993.
DOI : 10.1126/science.8493556

J. P. Pearson, K. M. Gray, L. Passador, K. D. Tucker, A. Eberhard et al., Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes., Proceedings of the National Academy of Sciences, vol.91, issue.1, pp.197-201, 1994.
DOI : 10.1073/pnas.91.1.197

M. Pirhonen, D. Flego, R. Heikinheimo, and E. T. Palva, A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogen Erwinia carotovora, EMBO J, vol.12, pp.2467-2476, 1993.

A. P. Pugsley, The complete general secretory pathway in Gram-negative bacteria, Microbiol Rev, vol.57, pp.50-108, 1993.

P. J. Reeves, D. Whitcombe, S. Wharam, M. Gibson, G. Allison et al., Molecular cloning and characterization of 13 out genes from Erwinia carotovora subspecies carotovora: genes encoding members of a general secretion pathway (GSP) widespread in Gram-negative bacteria, Molecular Microbiology, vol.153, issue.3, pp.443-456, 1993.
DOI : 10.1016/0378-1119(91)90221-V

L. Rust, E. C. Pesci, and B. H. Iglewski, Analysis of the Pseudomonas aeruginosa elastase (lasB) regulatory region., Journal of Bacteriology, vol.178, issue.4, pp.1134-1140, 1996.
DOI : 10.1128/jb.178.4.1134-1140.1996

G. P. Salmond, B. W. Bycroft, G. S. Stewart, W. , and P. , The bacterial 'enigma': cracking the code of cell?cell communication, Molecular Microbiology, vol.10, issue.4, pp.615-624, 1995.
DOI : 10.1038/362446a0

V. D. Shortridge, A. Lazdunski, and M. L. Vasil, Osmoprotectants and phosphate regulate expression of phospholipase C in Pseudomonas aeruginosa, Molecular Microbiology, vol.136, issue.7, pp.863-871, 1992.
DOI : 10.1164/ajrccm/136.2.426

H. P. Spaink, R. J. Okker, C. A. Wijffelman, E. Pees, and B. J. Lugtenberg, Promoters in the nodulation region of the Rhizobium leguminosarum Sym plasmid pRL1JI, Plant Molecular Biology, vol.33, issue.1, pp.27-39, 1987.
DOI : 10.1007/978-3-642-71652-2_12

D. S. Toder, M. J. Gambello, and B. H. Iglewski, Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR, Molecular Microbiology, vol.36, issue.8, pp.2003-2010, 1991.
DOI : 10.1038/nbt1183-784

D. S. Toder, S. J. Ferrel, J. L. Nezezon, L. Rust, and B. H. Iglewski, ) lasA and lasB genes of Pseudomonas aeruginosa: analysis of transcription and gene product activity, Infect Immun, vol.62, pp.1320-1327, 1994.

M. L. Vasil, R. M. Berka, G. L. Gray, and O. R. Pavlovskis, Biochemical and Genetic Studies of Iron-Regulated (Exotoxin A) and Phosphate-Regulated (Hemolysin Phospholipase C) Virulence Factors of Pseudomonas aeruginosal1, Antibiot Chemother, vol.36, pp.23-39, 1985.
DOI : 10.1159/000410469

M. A. Whooley, J. A. O-'callaghan, and A. J. Mcloughlin, Effect of Substrate on the Regulation of Exoprotease Production by Pseudomonas aeruginosa ATCC 10145, Microbiology, vol.129, issue.4, pp.981-988, 1983.
DOI : 10.1099/00221287-129-4-981

M. K. Winson, M. Camara, A. Latifi, M. Foglino, S. R. Chhabra et al., Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa., Proceedings of the National Academy of Sciences, vol.92, issue.20, pp.9427-9431, 1995.
DOI : 10.1073/pnas.92.20.9427

URL : https://hal.archives-ouvertes.fr/hal-01560869

B. Wretlind and O. R. Pavlovskis, Genetic mapping and characterization of Pseudomonas aeruginosa mutants defective in the formation of extracellular proteins, J Bacteriol, vol.158, pp.801-808, 1984.

Z. You, J. Fukushima, T. Ishiwata, B. Chang, M. Kurata et al., Purification and characterization of LasR as a DNA-binding protein, FEMS Microbiology Letters, vol.142, issue.2-3, pp.301-307, 1996.
DOI : 10.1111/j.1574-6968.1996.tb08447.x