Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis - Archive ouverte HAL Access content directly
Journal Articles Genes and Immunity Year : 2007

Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis

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1
B. Bucheton
  • Function : Author
L. Argiro
  • Function : Author
S. Marquet
M. M. Kheir
  • Function : Author
A. Mergani
  • Function : Author
S. H. El-Safi
  • Function : Author
A. J. Dessein
  • Function : Author

Abstract

Binding of the interleukin-2 (IL-2) to the IL-2 receptor (IL-2R) triggers a series of intracellular events culminating in lymphocyte proliferation and differentiation. We report here the identification of a novel G245R polymorphism in the membrane proximal domain of the IL-2 receptor beta chain (IL-2Rbeta). Present at a frequency of 7.2%, the IL-2-Rbeta G245R was identified in a population of Eastern Sudan exposed to a severe outbreak of visceral leishmaniasis (VL), a disease associated with a marked depression of T-cell antigen-specific responses. The location of the G245R polymorphism next to the box1/box2 proximal cytokine receptor homology segment and suggestive genetic association with the development of disease (P=0.043), suggest that it may affect Janus kinase (JAK) association and impair growth signal transduction. However, additional genetic association with a synonymous single nucleotide polymorphism (IL2RB+8777T) suggests that other variations of IL2RB or nearby genes participate in the highly significant linkage with VL at 22q12 previously reported for this population.

Dates and versions

hal-01592707 , version 1 (25-09-2017)

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B. Bucheton, L. Argiro, C. Chevillard, S. Marquet, M. M. Kheir, et al.. Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis. Genes and Immunity, 2007, 8 (1), pp.79-83. ⟨10.1038/sj.gene.6364355⟩. ⟨hal-01592707⟩

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