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Le contrôle génétique des hyperéosinophilies

Abstract : Polynuclear eosinophils play a major role in host defe11se against infectious diseases and especially helminthiasis. 011Set of hypereosinophilia can be attri-buted to two mechanisms which can occur separately or in combination. The first mechanism involves enha11ce-ment of medullary production and differentiation of eosi-nophils. The second is prolonged life span of eosinophils. Response to eosinophils depends on various cytokines including IL-5, JL-4, JL-3 and GM-CSF. Since it contains the genes codingfor these cytokines, the Sq31-q33 region of chromosome 5 is the focus of study on gene-tic control of human hypereosinophilia. The goal of these studies is to allow screening of subjects predisposed to hel-minthic infection and to deregulation of immune res-ponses that may lead to atopy and various types systemic inflammatory diseases.
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Contributor : Lionel Spinelli Connect in order to contact the contributor
Submitted on : Thursday, December 6, 2018 - 10:08:27 AM
Last modification on : Friday, March 4, 2022 - 9:36:03 AM
Long-term archiving on: : Thursday, March 7, 2019 - 1:11:23 PM


Distributed under a Creative Commons Attribution 4.0 International License


  • HAL Id : hal-01593095, version 1



B Granel, P Disdier, N Schleinitz, Christophe Chevillard, J R Harle, et al.. Le contrôle génétique des hyperéosinophilies. Medecine Tropicale, 1998, 58 (4 Suppl), pp.508-11. ⟨hal-01593095⟩



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