Le contrôle génétique des hyperéosinophilies

Abstract : Polynuclear eosinophils play a major role in host defe11se against infectious diseases and especially helminthiasis. 011Set of hypereosinophilia can be attri-buted to two mechanisms which can occur separately or in combination. The first mechanism involves enha11ce-ment of medullary production and differentiation of eosi-nophils. The second is prolonged life span of eosinophils. Response to eosinophils depends on various cytokines including IL-5, JL-4, JL-3 and GM-CSF. Since it contains the genes codingfor these cytokines, the Sq31-q33 region of chromosome 5 is the focus of study on gene-tic control of human hypereosinophilia. The goal of these studies is to allow screening of subjects predisposed to hel-minthic infection and to deregulation of immune res-ponses that may lead to atopy and various types systemic inflammatory diseases.
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-01593095
Contributor : Lionel Spinelli <>
Submitted on : Thursday, December 6, 2018 - 10:08:27 AM
Last modification on : Friday, May 17, 2019 - 3:04:24 PM
Long-term archiving on : Thursday, March 7, 2019 - 1:11:23 PM

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

  • HAL Id : hal-01593095, version 1

Collections

Citation

B Granel, P Disdier, N Schleinitz, Christophe Chevillard, J R Harle, et al.. Le contrôle génétique des hyperéosinophilies. Medecine Tropicale, Institut de Medecine Tropicale, 1998, 58 (4 Suppl), pp.508-11. ⟨hal-01593095⟩

Share

Metrics

Record views

51

Files downloads

14