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Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells

G. Jego 1 N. Robillard 2 Denis Puthier 3 M. Amiot 4 F. Accard D. Pineau J. L. Harousseau 2 R. Bataille 2 C. Pellat-Deceunynck
1 LNC - Lipides - Nutrition - Cancer (U866)
2 On behalf of the IFM group
3 Service d'Hématologie Clinique [Hôtel Dieu, Nantes]
4 NORT - Nutrition, obésité et risque thrombotique
Abstract : Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19(+) CD38(+) CD138(+) CD40(+) CD45(+) CD11a+ CD49e- CD56(-)). In most cases, a minor subpopulation of CD28(+) plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138(+) plasma cell removal, highly proliferative CD138(-) plasmablasts differentiated into CD138(+) plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and was concomitant with extensive secretion of interleukin-6 (IL-6). The addition of neutralizing anti-IL-6 and anti-CD126 (IL-6 receptor) monoclonal antibodies totally prevented Ig secretion and cell differentiation by inducing apoptosis of plasmablasts, which indicates that IL-6 is an essential survival factor for plasmablasts. This report provides the first characterization of normal plasmablasts and shows that their phenotype is not exactly that of multiple myeloma cells.
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https://hal-amu.archives-ouvertes.fr/hal-01595831
Contributor : Lionel Spinelli Connect in order to contact the contributor
Submitted on : Wednesday, September 27, 2017 - 9:28:38 AM
Last modification on : Tuesday, October 19, 2021 - 10:59:25 PM

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  • HAL Id : hal-01595831, version 1

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UNIV-AMU | INRA | UNIV-BOURGOGNE | LNC-UMR866 | ENSBANA | AGROSUP-DIJON | INRAE

Citation

G. Jego, N. Robillard, Denis Puthier, M. Amiot, F. Accard, et al.. Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells. Blood, American Society of Hematology, 1999, 94 (2), pp.701--712. ⟨hal-01595831⟩

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