Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells

G. Jego; N. Robillard; Denis Puthier; M. Amiot; F. Accard; D. Pineau; J. L. Harousseau; R. Bataille; C. Pellat-Deceunynck

Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells

G. Jego ¹ N. Robillard ² Denis Puthier ³ M. Amiot ⁴ F. Accard D. Pineau J. L. Harousseau ² R. Bataille ² C. Pellat-Deceunynck

1 LNC - Lipides - Nutrition - Cancer (U866)

2 On behalf of the IFM group

3 Service d'Hématologie Clinique [Hôtel Dieu, Nantes]

4 NORT - Nutrition, obésité et risque thrombotique

Abstract : Circulating plasma cells in 10 cases of reactive plasmacytosis had a shared phenotype with early plasma cell (CD19(+) CD38(+) CD138(+) CD40(+) CD45(+) CD11a+ CD49e- CD56(-)). In most cases, a minor subpopulation of CD28(+) plasma cells was also detected. Reactive plasma cells were highly proliferative, suggesting the presence of circulating progenitors (plasmablasts). After CD138(+) plasma cell removal, highly proliferative CD138(-) plasmablasts differentiated into CD138(+) plasma cells within a few days. This differentiation, which was associated with increased CD38 and decreased HLA-DR expression, was further confirmed by a large increase in intracellular Ig content (associated with Ig secretion) and was concomitant with extensive secretion of interleukin-6 (IL-6). The addition of neutralizing anti-IL-6 and anti-CD126 (IL-6 receptor) monoclonal antibodies totally prevented Ig secretion and cell differentiation by inducing apoptosis of plasmablasts, which indicates that IL-6 is an essential survival factor for plasmablasts. This report provides the first characterization of normal plasmablasts and shows that their phenotype is not exactly that of multiple myeloma cells.

Type de document :

Article dans une revue

Blood, American Society of Hematology, 1999, 94 (2), pp.701--712

Domaine :

Informatique [cs] / Bio-informatique [q-bio.QM]

Liste complète des métadonnées

https://hal-amu.archives-ouvertes.fr/hal-01595831
Contributeur : Lionel Spinelli <>
Soumis le : mercredi 27 septembre 2017 - 09:28:38
Dernière modification le : vendredi 8 juin 2018 - 14:50:12

Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells

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Reactive plasmacytoses are expansions of plasmablasts retaining the capacity to differentiate into plasma cells

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