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Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells

Abstract : Multiple myeloma (MM) is a slowly proliferative malignancy in which malignant plasma cells accumulate within the bone marrow. The expression of several anti-apoptotic proteins was evaluated by immunoblotting in human myeloma cell lines and in highly purified native myeloma cells. Expression of Bcl-xL, Mcl-1 and Bcl-2 was found in most of the samples; expression of Bcl-xL and Mcl-1 seemed to be related on myeloma cells. In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and Bcl-xL were tightly regulated by interleukin (IL)-6. These findings underline the important role of Mcl-1 and Bcl-xL instead of Bcl-2 in IL-6-induced survival of myeloma cells.
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Contributor : Lionel Spinelli Connect in order to contact the contributor
Submitted on : Wednesday, September 27, 2017 - 9:28:42 AM
Last modification on : Thursday, March 17, 2022 - 10:08:38 AM


  • HAL Id : hal-01595834, version 1


Denis Puthier, S. Derenne, S. Barille, P. Moreau, J. L. Harousseau, et al.. Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells. Br. J. Haematol., 1999, 107 (2), pp.392--395. ⟨hal-01595834⟩



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