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Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population

Abstract : Several studies have provided evidence of both helpful and harmful effects of TNF on the outcome of Plasmodium falciparum malaria infection. Several TNF polymorphisms that are located within non-coding regions have been associated with parasitaemia, mild malaria or severe malaria. We investigated the association of TNF1304 (rs3093664), TNF-308 (rs1800629), TNF-238 (rs361525) and TNF-244 (rs673) with mild malaria and symptomatic maximum parasitaemia in a population-based design (n=310). We obtained nominal evidence for an association between symptomatic maximum parasitaemia and TNF-308, TNF-238, and TNF-244 on the one hand, and between the number of mild malaria attacks and TNF-244 on the other hand. After accounting for multiple tests, we confirmed the association of symptomatic maximum parasitaemia with TNF-244. We further provide bioinformatics and experimental evidence that TNF-244 has a cis-regulatory effect. This is the first report that emphasizes the potential role of TNF-244 in malaria.Genes and Immunity advance online publication, 13 July 2017; doi:10.1038/gene.2017.13.
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Submitted on : Wednesday, September 27, 2017 - 10:07:40 AM
Last modification on : Monday, August 12, 2019 - 5:02:06 PM

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T. N. Nguyen, S. Baaklini, F. Koukouikila-Koussounda, M. Ndounga, M. Torres, et al.. Association of a functional TNF variant with Plasmodium falciparum parasitaemia in a congolese population. Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2017, ⟨10.1038/gene.2017.13⟩. ⟨hal-01595896⟩

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