F. Axelrod, K. Iyer, I. Fish, J. Pearson, and M. Sein, Progressive sensory loss in familial dysautonomia, Pediatrics, vol.67, pp.517-539, 1981.

J. Pearson, B. Pytel, N. Grover-johnson, F. Axelrod, and J. Dancis, Quantitative studies of dorsal root ganglia and neuropathologic observations on spinal cords in familial dysautonomia, Journal of the Neurological Sciences, vol.35, issue.1, pp.77-92, 1978.
DOI : 10.1016/0022-510X(78)90103-X

J. Pearson and B. Pytel, Quantitative studies of sympathetic ganglia and spinal cord intermedio-lateral gray columns in familial dysautonomia, Journal of the Neurological Sciences, vol.39, issue.1, pp.47-59, 1978.
DOI : 10.1016/0022-510X(78)90187-9

F. Axelrod, Familial dysautonomia, Muscle & Nerve, vol.294, issue.3, pp.352-63, 2004.
DOI : 10.1148/radiology.142.1.7053554
URL : https://hal.archives-ouvertes.fr/hal-01612145

S. Anderson, R. Coli, I. Daly, E. Kichula, and M. Rork, Familial Dysautonomia Is Caused by Mutations of the IKAP Gene, The American Journal of Human Genetics, vol.68, issue.3, pp.753-761, 2001.
DOI : 10.1086/318808

S. Slaugenhaupt, A. Blumenfeld, S. Gill, M. Leyne, and J. Mull, Tissue-Specific Expression of a Splicing Mutation in the IKBKAP Gene Causes Familial Dysautonomia, The American Journal of Human Genetics, vol.68, issue.3, pp.598-605, 2001.
DOI : 10.1086/318810

J. Dong, L. Edelmann, A. Bajwa, R. Kornreich, and R. Desnick, Familial dysautonomia: Detection of theIKBKAP IVS20+6T ? C and R696P mutations and frequencies among Ashkenazi Jews, American Journal of Medical Genetics, vol.147, issue.3, pp.253-260, 2002.
DOI : 10.1126/science.147.3661.1040

M. Cuajungco, M. Leyne, J. Mull, S. Gill, and W. Lu, Tissue-Specific Reduction in Splicing Efficiency of IKBKAP Due to the Major Mutation Associated with Familial Dysautonomia, The American Journal of Human Genetics, vol.72, issue.3, pp.749-58, 2003.
DOI : 10.1086/368263

N. Hawkes, G. Otero, G. Winkler, N. Marshall, and M. Dahmus, Purification and Characterization of the Human Elongator Complex, Journal of Biological Chemistry, vol.268, issue.4, pp.3047-52, 2002.
DOI : 10.1093/nar/22.22.4673

P. Close, N. Hawkes, I. Cornez, C. Creppe, and C. Lambert, Transcription Impairment and Cell Migration Defects in Elongator-Depleted Cells: Implication for Familial Dysautonomia, Molecular Cell, vol.22, issue.4, pp.521-552, 2006.
DOI : 10.1016/j.molcel.2006.04.017

C. Creppe, L. Malinouskaya, M. Volvert, M. Gillard, and P. Close, Elongator Controls the Migration and Differentiation of Cortical Neurons through Acetylation of ??-Tubulin, Cell, vol.136, issue.3, pp.551-64, 2009.
DOI : 10.1016/j.cell.2008.11.043

J. Solinger, R. Paolinelli, H. Kloss, F. Scorza, and S. Marchesi, The Caenorhabditis elegans Elongator Complex Regulates Neuronal ??-tubulin Acetylation, PLoS Genetics, vol.1154, issue.3, p.1000820, 2010.
DOI : 10.1371/journal.pgen.1000820.s008

C. Chen, S. Tuck, and A. Bystrom, Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in Caenorhabditis elegans Elongator Mutants, PLoS Genetics, vol.4, issue.3, p.1000561, 2009.
DOI : 10.1371/journal.pgen.1000561.s011

B. Huang, M. Johansson, and A. Bystrom, An early step in wobble uridine tRNA modification requires the Elongator complex, RNA, vol.11, issue.4, pp.424-460, 2005.
DOI : 10.1261/rna.7247705

P. Graziadei and G. Graziadei, Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons, Journal of Neurocytology, vol.60, issue.1, pp.1-18, 1979.
DOI : 10.1007/BF01206454

W. Murrell, F. Feron, A. Wetzig, N. Cameron, and K. Splatt, Multipotent stem cells from adult olfactory mucosa, Developmental Dynamics, vol.7, issue.2, pp.496-515, 2005.
DOI : 10.1177/22.12.1077
URL : https://hal.archives-ouvertes.fr/hal-00093306

B. Delorme, E. Nivet, J. Gaillard, T. Haupl, and J. Ringe, The Human Nose Harbors a Niche of Olfactory Ectomesenchymal Stem Cells Displaying Neurogenic and Osteogenic Properties, Stem Cells and Development, vol.19, issue.6, pp.853-66, 2010.
DOI : 10.1089/scd.2009.0267

F. Feron, C. Perry, M. Hirning, J. Mcgrath, and A. Mackay-sim, Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia, Schizophrenia Research, vol.40, issue.3, pp.211-219, 1999.
DOI : 10.1016/S0920-9964(99)00055-9
URL : https://hal.archives-ouvertes.fr/hal-00094334

R. Mccurdy, F. Feron, C. Perry, D. Chant, and D. Mclean, Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses, Schizophrenia Research, vol.82, issue.2-3, pp.163-73, 2006.
DOI : 10.1016/j.schres.2005.10.012

W. Murrell, A. Wetzig, M. Donnellan, F. Feron, and T. Burne, Olfactory Mucosa Is a Potential Source for Autologous Stem Cell Therapy for Parkinson's Disease, Stem Cells, vol.23, issue.8, pp.2183-92, 2008.
DOI : 10.1001/archneur.1990.00530120030006

L. Johansen, T. Naumanen, A. Knudsen, N. Westerlund, and I. Gromova, IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration, Journal of Cell Science, vol.121, issue.6, pp.854-64, 2008.
DOI : 10.1242/jcs.013722

S. Slaugenhaupt, J. Mull, M. Leyne, M. Cuajungco, and S. Gill, Rescue of a human mRNA splicing defect by the plant cytokinin kinetin, Human Molecular Genetics, vol.13, issue.4, pp.429-465, 2004.
DOI : 10.1093/hmg/ddh046

M. Hims, E. Ibrahim, M. Leyne, J. Mull, and L. Liu, Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia, Journal of Molecular Medicine, vol.10, issue.2, pp.149-61, 2007.
DOI : 10.1128/MCB.13.6.3660
URL : https://hal.archives-ouvertes.fr/hal-00320234

G. Gold-von-simson, J. Goldberg, L. Rolnitzky, J. Mull, and M. Leyne, Kinetin in Familial Dysautonomia Carriers: Implications for a New Therapeutic Strategy Targeting mRNA Splicing, Pediatric Research, vol.85, issue.3, pp.341-347, 2009.
DOI : 10.1007/s00109-006-0144-3

S. Tanabe, Y. Sato, T. Suzuki, K. Suzuki, and T. Nagao, Gene Expression Profiling of Human Mesenchymal Stem Cells for Identification of Novel Markers in Early- and Late-Stage Cell Culture, The Journal of Biochemistry, vol.144, issue.3, pp.399-408, 2008.
DOI : 10.1093/jb/mvn082

W. Wagner, P. Horn, M. Castoldi, A. Diehlmann, and S. Bork, Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process, PLoS ONE, vol.43, issue.5, p.2213, 2008.
DOI : 10.1371/journal.pone.0002213.t002

D. Cheishvili, C. Maayan, Y. Smith, G. Ast, and A. Razin, IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination, Human Molecular Genetics, vol.16, issue.17, pp.2097-104, 2007.
DOI : 10.1093/hmg/ddm157

X. Zhang, K. Klueber, Z. Guo, J. Cai, and C. Lu, Induction of neuronal differentiation of adult human olfactory neuroepithelial-derived progenitors, Brain Research, vol.1073, issue.1074, pp.1073-1074, 2006.
DOI : 10.1016/j.brainres.2005.12.059

B. Wolozin, T. Sunderland, B. Zheng, J. Resau, and B. Dufy, Continuous culture of neuronal cells from adult human olfactory epithelium, Journal of Molecular Neuroscience, vol.66, issue.3, pp.137-183, 1992.
DOI : 10.1001/archotol.1982.00790520047013

F. Roisen, K. Klueber, C. Lu, L. Hatcher, and A. Dozier, Adult human olfactory stem cells, Brain Research, vol.890, issue.1, pp.11-22, 2001.
DOI : 10.1016/S0006-8993(00)03016-X

X. Zhang, K. Klueber, Z. Guo, C. Lu, and F. Roisen, Adult human olfactory neural progenitors cultured in defined medium, Experimental Neurology, vol.186, issue.2, pp.112-135, 2004.
DOI : 10.1016/j.expneurol.2003.10.022

W. Winstead, C. Marshall, C. Lu, K. Klueber, and F. Roisen, Endoscopic biopsy of human olfactory epithelium as a source of progenitor cells, Am J Rhinol, vol.19, pp.83-90, 2005.

F. Feron, C. Perry, J. Mcgrath, and A. Mackay-sim, New Techniques for Biopsy and Culture of Human Olfactory Epithelial Neurons, Archives of Otolaryngology???Head & Neck Surgery, vol.124, issue.8, pp.861-867, 1998.
DOI : 10.1001/archotol.124.8.861

M. Othman, C. Lu, K. Klueber, W. Winstead, and F. Roisen, Clonal analysis of adult human olfactory neurosphere forming cells, Biotechnic & Histochemistry, vol.186, issue.5-6, pp.189-200, 2005.
DOI : 10.1016/j.expneurol.2003.10.022

M. Viegas, N. Gehring, S. Breit, M. Hentze, and A. Kulozik, The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway, Nucleic Acids Research, vol.35, issue.13, pp.4542-51, 2007.
DOI : 10.1093/nar/gkm461

J. Bateman, S. Freddi, G. Nattrass, and R. Savarirayan, Tissue-specific RNA surveillance? Nonsense-mediated mRNA decay causes collagen X haploinsufficiency in Schmid metaphyseal chondrodysplasia cartilage, Human Molecular Genetics, vol.12, issue.3, pp.217-242, 2003.
DOI : 10.1093/hmg/ddg054

N. Resta, F. Susca, D. Giacomo, M. Stella, A. Bukvic et al., A homozygous frameshift mutation in theESCO2 gene: Evidence of intertissue and interindividual variation in Nmd efficiency, Journal of Cellular Physiology, vol.349, issue.1, pp.67-73, 2006.
DOI : 10.1002/jcp.20708

C. Holmberg, S. Katz, M. Lerdrup, T. Herdegen, and M. Jaattela, A Novel Specific Role for I??B Kinase Complex-associated Protein in Cytosolic Stress Signaling, Journal of Biological Chemistry, vol.3, issue.35, pp.31918-31946, 2002.
DOI : 10.1126/science.270.5240.1326

J. Kim, W. Lane, and D. Reinberg, Human Elongator facilitates RNA polymerase II transcription through chromatin, Proceedings of the National Academy of Sciences, vol.94, issue.4, pp.1241-1247, 2002.
DOI : 10.1016/S0092-8674(00)81585-8

I. Cornez, C. Creppe, M. Gillard, B. Hennuy, and J. Chapelle, Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells, Biochemical Pharmacology, vol.75, issue.11, pp.2122-2156, 2008.
DOI : 10.1016/j.bcp.2008.03.006

Y. Watanabe, S. Itoh, T. Goto, E. Ohnishi, and M. Inamitsu, TMEPAI, a Transmembrane TGF-??-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-?? Signaling, Molecular Cell, vol.37, issue.1, pp.123-157, 2010.
DOI : 10.1016/j.molcel.2009.10.028

S. Stamm, J. Riethoven, L. Texier, V. Gopalakrishnan, C. Kumanduri et al., ASD: a bioinformatics resource on alternative splicing, Nucleic Acids Research, vol.34, issue.90001, pp.46-55, 2006.
DOI : 10.1093/nar/gkj031
URL : https://academic.oup.com/nar/article-pdf/34/suppl_1/D46/3923831/gkj031.pdf

L. Cohen, W. Henzel, and P. Baeuerle, IKAP is a scaffold protein of the IkappaB kinase complex, Nature, vol.395, pp.292-298, 1998.

E. Pros, J. Fernandez-rodriguez, L. Benito, A. Ravella, and G. Capella, Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment, European Journal of Human Genetics, vol.16, issue.5, 2009.
DOI : 10.1203/PDR.0b013e318194fd52

I. Viktorov, E. Savchenko, and V. Chekhonin, Spontaneous neural differentiation of stem cells in culture of human olfactory epithelium, Bulletin of Experimental Biology and Medicine, vol.186, issue.2, pp.596-601, 2007.
DOI : 10.1016/j.brainres.2005.03.041

I. Carmel, S. Tal, I. Vig, and G. Ast, Comparative analysis detects dependencies among the 5' splice-site positions, RNA, vol.10, issue.5, pp.828-868, 2004.
DOI : 10.1261/rna.5196404

E. Ibrahim, M. Hims, N. Shomron, C. Burge, and S. Slaugenhaupt, exon 20 leads to aberrant splicing in familial dysautonomia, Human Mutation, vol.10, issue.1, pp.41-53, 2007.
DOI : 10.1128/MCB.13.8.4939
URL : https://hal.archives-ouvertes.fr/hal-00320236

J. Ule, A. Ule, J. Spencer, A. Williams, and J. Hu, Nova regulates brain-specific splicing to shape the synapse, Nature Genetics, vol.2452, issue.8, pp.844-52, 2005.
DOI : 10.1128/MCB.17.6.3194

E. Beillard, N. Pallisgaard, V. Van-der-velden, W. Bi, and R. Dee, Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using ???real-time??? quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) ??? a Europe against cancer program, Leukemia, vol.17, issue.12, pp.2474-86, 2003.
DOI : 10.1038/sj.leu.2403136

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-410, 2001.
DOI : 10.1006/meth.2001.1262

B. Ballester, O. Ramuz, C. Gisselbrecht, G. Doucet, and L. Loi, Gene expression profiling identifies molecular subgroups among nodal peripheral T-cell lymphomas, Oncogene, vol.89, issue.10, pp.1560-70, 2006.
DOI : 10.1186/gb-2003-4-4-r28
URL : https://hal.archives-ouvertes.fr/hal-01612147

L. Talby, H. Chambost, M. Roubaud, N. Guyen, C. Milili et al., The chemosensitivity to therapy of childhood early B acute lymphoblastic leukemia could be determined by the combined expression of CD34, SPI-B and BCR genes, Leukemia Research, vol.30, issue.6, pp.665-76, 2006.
DOI : 10.1016/j.leukres.2005.10.007
URL : https://hal.archives-ouvertes.fr/hal-00080179

F. Lopez, J. Rougemont, B. Loriod, A. Bourgeois, and L. Loi, Feature extraction and signal processing for nylon DNA microarrays, BMC Genomics, vol.5, issue.1, p.38, 2004.
DOI : 10.1186/1471-2164-5-38
URL : https://hal.archives-ouvertes.fr/inserm-00112016

R. Gentleman, V. Carey, D. Bates, B. Bolstad, and M. Dettling, Bioconductor: open software development for computational biology and bioinformatics, Genome Biology, vol.5, issue.10, p.80, 2004.
DOI : 10.1186/gb-2004-5-10-r80