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Article Dans Une Revue Critical Care Année : 2014

Approaches combining mice and Drosophila melanogaster models to decipher human sepsis

Résumé

Sepsis is a complex and heterogeneous syndrome in which inflammatory and infection mechanisms are implicated. Thus, it is difficult to differentiate those mechanisms in mammals where inflammation is a highly complex biological process. In our laboratory, besides studying sepsis in human blood biological samples, we choose to investigate a murine model in ordered to describe a global transcriptome overview of critical events occurring in the blood, brain and lung during an induced non-infection inflammation. We decided to complete our view with another animal model where the inflammatory process is less complex and mainly achieved through innate immunity Drosophila melanogaster.
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Dates et versions

hal-01619083 , version 1 (19-10-2023)

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Paternité

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R Ramy, S Garnier, Lydie Pradel, Laurence Röder, Béatrice B. Loriod, et al.. Approaches combining mice and Drosophila melanogaster models to decipher human sepsis. Critical Care, 2014, 18 (S2), ⟨10.1186/cc14070⟩. ⟨hal-01619083⟩
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