Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C, J Biol Chem, vol.268, pp.16321-16326, 1993. ,
Nuclear Lamins: Laminopathies and Their Role in Premature Ageing, Physiological Reviews, vol.86, issue.3, pp.967-1008, 2006. ,
DOI : 10.1152/physrev.00047.2005
URL : http://physrev.physiology.org/content/physrev/86/3/967.full.pdf
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin, Genes & Development, vol.22, issue.7, pp.832-853, 2008. ,
DOI : 10.1101/gad.1652708
Nuclear lamins: key regulators of nuclear structure and activities, Journal of Cellular and Molecular Medicine, vol.17, issue.6, pp.1059-1085, 2009. ,
DOI : 10.1002/ajmg.a.31803
Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina., Proceedings of the National Academy of Sciences, vol.89, issue.7, pp.3000-3004, 1992. ,
DOI : 10.1073/pnas.89.7.3000
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect, Proceedings of the National Academy of Sciences, vol.102, issue.4, pp.13049-13054, 2002. ,
DOI : 10.1002/ajmg.1463
by recombinant Zmpste24, Biochemical Journal, vol.387, issue.1, pp.129-138, 2005. ,
DOI : 10.1042/BJ20041359
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase???deficient mice, Nature Genetics, vol.31, pp.94-99, 2002. ,
DOI : 10.1038/ng871
Role of A-type lamins in signaling, transcription, and chromatin organization, The Journal of Cell Biology, vol.270, issue.7, pp.945-957, 2009. ,
DOI : 10.1016/j.bbrc.2005.10.020
Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy, Nature Genetics, vol.21, issue.3, pp.285-288, 1999. ,
DOI : 10.1038/6799
Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease, New England Journal of Medicine, vol.341, issue.23, pp.1715-1724, 1999. ,
DOI : 10.1056/NEJM199912023412302
Identification of mutations in the gene encoding lamins A/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B), Human Molecular Genetics, vol.9, issue.9, pp.1453-1459, 2000. ,
DOI : 10.1093/hmg/9.9.1453
Homozygous Defects in LMNA, Encoding Lamin A/C Nuclear-Envelope Proteins, Cause Autosomal Recessive Axonal Neuropathy in Human (Charcot-Marie-Tooth Disorder Type 2) and Mouse, The American Journal of Human Genetics, vol.70, issue.3, pp.726-736, 2002. ,
DOI : 10.1086/339274
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy, Nature Genetics, vol.112, issue.2, pp.153-156, 2000. ,
DOI : 10.1046/j.1523-1747.1999.00613.x
Mutations in Patients with Severe Metabolic Syndrome, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.12, pp.4835-4844, 2007. ,
DOI : 10.1210/jc.2007-0654
High prevalence of laminopathies among patients with metabolic syndrome, Human Molecular Genetics, vol.20, issue.19, pp.3779-3786, 2011. ,
DOI : 10.1093/hmg/ddr294
Recurrent de novo point mutations in lamin A cause Hutchinson???Gilford progeria syndrome, Nature, vol.66, issue.6937, pp.293-298, 2003. ,
DOI : 10.1086/302836
Molecular bases of progeroid syndromes, Human Molecular Genetics, vol.15, issue.suppl_2, pp.151-161, 2006. ,
DOI : 10.1093/hmg/ddl214
Hutchinson???Gilford progeria syndrome: Review of the phenotype, American Journal of Medical Genetics Part A, vol.81, issue.23, pp.2603-2624, 2006. ,
DOI : 10.1016/S1388-1981(02)00342-6
Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy, Human Molecular Genetics, vol.13, issue.20, pp.2493-2503, 2004. ,
DOI : 10.1093/hmg/ddh265
URL : https://hal.archives-ouvertes.fr/hal-01668977
Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors, Human Molecular Genetics, vol.14, issue.11, pp.1503-1513, 2005. ,
DOI : 10.1093/hmg/ddi159
Lamin A-Dependent Nuclear Defects in Human Aging, Science, vol.312, issue.5776, pp.1059-1063, 2006. ,
DOI : 10.1126/science.1127168
Prelamin A Acts to Accelerate Smooth Muscle Cell Senescence and Is a Novel Biomarker of Human Vascular Aging, Circulation, vol.121, issue.20, pp.2200-2210, 2010. ,
DOI : 10.1161/CIRCULATIONAHA.109.902056
HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity, BMJ, vol.338, issue.jan26 2, p.3172, 2009. ,
DOI : 10.1136/bmj.a3172
HIV Infection, Inflammation, Immunosenescence, and Aging, Annual Review of Medicine, vol.62, issue.1, pp.141-155, 2011. ,
DOI : 10.1146/annurev-med-042909-093756
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759035/pdf
Lipodystrophies: Genetic and Acquired Body Fat Disorders, The Journal of Clinical Endocrinology & Metabolism, vol.96, issue.11, pp.3313-3325, 2011. ,
DOI : 10.1210/jc.2011-1159
Premature Age-Related Comorbidities Among HIV-Infected Persons Compared With the General Population, Clinical Infectious Diseases, vol.53, issue.11, pp.1120-1126, 2011. ,
DOI : 10.1093/cid/cir627
URL : https://academic.oup.com/cid/article-pdf/53/11/1120/865121/cir627.pdf
Fate of the Inner Nuclear Membrane Protein Lamin B Receptor and Nuclear Lamins in Herpes Simplex Virus Type 1 Infection, Journal of Virology, vol.75, issue.18, pp.8818-8830, 2001. ,
DOI : 10.1128/JVI.75.18.8818-8830.2001
Cytomegalovirus Recruitment of Cellular Kinases to Dissolve the Nuclear Lamina, Science, vol.297, issue.5582, pp.854-857, 2002. ,
DOI : 10.1126/science.1071506
Dynamic Disruptions in Nuclear Envelope Architecture and Integrity Induced by HIV-1 Vpr, Science, vol.294, issue.5544, pp.1105-1108, 2001. ,
DOI : 10.1126/science.1063957
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells, Proceedings of the National Academy of Sciences, vol.22, issue.22, pp.13432-13437, 2007. ,
DOI : 10.1093/emboj/cdg571
A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells, Journal of Biological Chemistry, vol.67, issue.15, pp.9797-9804, 2008. ,
DOI : 10.2165/00003495-200767180-00010
Dynamics of Lamin-A Processing Following Precursor Accumulation, PLoS ONE, vol.272, issue.5, p.10874, 2010. ,
DOI : 10.1371/journal.pone.0010874.s004
Premature Senescence of Vascular Cells Is Induced by HIV Protease Inhibitors: Implication of Prelamin A and Reversion by Statin, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.30, issue.12, pp.2611-2620, 2010. ,
DOI : 10.1161/ATVBAHA.110.213603
LMNA Messenger RNA Expression in Highly Active Antiretroviral Therapy-Treated HIV-Positive Patients, JAIDS Journal of Acquired Immune Deficiency Syndromes, vol.46, issue.4, pp.384-389, 2007. ,
DOI : 10.1097/QAI.0b013e31815aba1b
URL : http://pdfs.journals.lww.com/jaids/2007/12010/LMNA_Messenger_RNA_Expression_in_Highly_Active.2.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506172169439;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdgN4iEYs15JjLUNJhcn8FAfBRzzRprlnqj3VHUky7nc4=;hash|9bEbHdtPWqVbtHugjUP0zQ==
Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence, Cell Death and Differentiation, vol.20, issue.10, pp.1759-1767, 2007. ,
DOI : 10.1006/excr.2000.4823
LMNA Mutations Induce a Non-Inflammatory Fibrosis and a Brown Fat-Like Dystrophy of Enlarged Cervical Adipose Tissue, The American Journal of Pathology, vol.179, issue.5, pp.2443-2453, 2011. ,
DOI : 10.1016/j.ajpath.2011.07.049
HIV-1 Infection and First Line ART Induced Differential Responses in Mitochondria from Blood Lymphocytes and Monocytes: The ANRS EP45 ???Aging??? Study, PLoS ONE, vol.32, issue.7, p.41129, 2012. ,
DOI : 10.1371/journal.pone.0041129.s009
URL : https://hal.archives-ouvertes.fr/hal-01646453
Simultaneous quantitative determination of the HIV protease inhibitors indinavir, amprenavir, ritonavir, lopinavir, saquinavir, nelfinavir and the nelfinavir active metabolite M8 in plasma by liquid chromatography, Journal of Chromatography B, vol.783, issue.2, pp.491-500, 2003. ,
DOI : 10.1016/S1570-0232(02)00728-6
Determination of the new HIV-protease inhibitor atazanavir by liquid chromatography after solid-phase extraction, Journal of Chromatography B, vol.810, issue.1, pp.25-34, 2004. ,
DOI : 10.1016/S1570-0232(04)00580-X
Determination of lopinavir and nevirapine by high-performance liquid chromatography after solid-phase extraction: application for the assessment of their transplacental passage at delivery, Journal of Chromatography B, vol.774, issue.2, pp.127-140, 2002. ,
DOI : 10.1016/S1570-0232(02)00169-1
Determination of ritonavir, a new HIV protease inhibitor, in biological samples using reversed-phase high-performance liquid chromatography, Journal of Chromatography B: Biomedical Sciences and Applications, vol.704, issue.1-2, pp.307-313, 1997. ,
DOI : 10.1016/S0378-4347(97)00454-4
Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection, Journal of Chromatography B: Biomedical Sciences and Applications, vol.719, issue.1-2, 1998. ,
DOI : 10.1016/S0378-4347(98)00392-2
Validation of an Electrospray Ionization LC-MS/MS Method for Quantitative Analysis of Raltegravir, Etravirine, and 9 Other Antiretroviral Agents in Human Plasma Samples, Therapeutic Drug Monitoring, vol.31, issue.6, pp.695-702, 2009. ,
DOI : 10.1097/FTD.0b013e3181c05adf
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging, Nature Medicine, vol.154, issue.7, pp.767-772, 2008. ,
DOI : 10.1172/JCI200422087
URL : https://hal.archives-ouvertes.fr/inserm-00376425
Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation, AIDS, vol.17, issue.17, pp.2437-2444, 2003. ,
DOI : 10.1097/00002030-200311210-00005
URL : http://pdfs.journals.lww.com/aidsonline/2003/11210/Some_HIV_protease_inhibitors_alter_lamin_A_C.5.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1504538561413;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdN2ziiHhY6wPF9tfA80junqMD2wtE6oUb5qXHb0AcZKI=;hash|wBK1qG/5HQ70n2XA2WzxXQ==
Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance, Accounts of Chemical Research, vol.41, issue.1, pp.78-86, 2008. ,
DOI : 10.1021/ar7001232
HIV-protease inhibitors block the enzymatic activity of purified Ste24p, HIVprotease inhibitors block the enzymatic activity of purified Ste24p, pp.365-368, 2008. ,
DOI : 10.1016/j.bbrc.2008.07.033
Prise en charge médicale des personnes infectées par le VIH Available: http://www.sante.gouv.fr/rapport-2010-sur-la- prise-en-charge-medicale-des-personnes-infectees-par, pp.978-980, 2010. ,
Antiretroviral drug toxicity in relation to pharmacokinetics, metabolic profile and pharmacogenetics, Expert Opinion on Drug Metabolism & Toxicology, vol.9, issue.5, 2011. ,
DOI : 10.1038/clpt.2009.12
Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action, Clinical Pharmacokinetics, vol.41, issue.11, pp.17-45, 2010. ,
DOI : 10.1111/j.1468-1293.2008.00513.x
URL : https://hal.archives-ouvertes.fr/inserm-00461125
The intracellular pharmacology of antiretroviral protease inhibitors, Journal of Antimicrobial Chemotherapy, vol.54, issue.6, pp.982-990, 2004. ,
DOI : 10.1093/jac/dkh487
Protein Binding in Antiretroviral Therapies, AIDS Research and Human Retroviruses, vol.19, issue.9, pp.825-835, 2003. ,
DOI : 10.1089/088922203769232629
Cultured CD4T cells and primary human lymphocytes express hOATPs: intracellular accumulation of saquinavir and lopinavir, British Journal of Pharmacology, vol.19, issue.Suppl 2, pp.875-883, 2008. ,
DOI : 10.1038/bjp.2008.320
HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms, Pharmacogenetics and Genomics, vol.20, issue.2, pp.112-120, 2010. ,
DOI : 10.1097/FPC.0b013e328335b02d
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859410/pdf
Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy, Journal of Medical Virology, vol.35, issue.5, pp.766-771, 2008. ,
DOI : 10.1002/jmv.21152
Lopinavir/Ritonavir, Drugs, vol.62, issue.2, pp.1275-1299, 2006. ,
DOI : 10.2165/00003495-200666090-00012
In vitro evidence of inhibition of mitochondrial protease processing by HIV-1 protease inhibitors in yeast: a possible contribution to lipodystrophy syndrome, Mitochondrion, vol.1, issue.6, pp.511-518, 2002. ,
DOI : 10.1016/S1567-7249(02)00042-9
Differences in the detection of three HIV-1 protease inhibitors in non-blood compartments: Clinical correlations, HIV Clinical Trials, vol.14, issue.1, pp.27-35, 2002. ,
DOI : 10.1086/319864
Antiretroviral Tissue Kinetics: In Vivo Imaging Using Positron Emission Tomography, Antimicrobial Agents and Chemotherapy, vol.53, issue.10, pp.4089-4095, 2009. ,
DOI : 10.1128/AAC.00419-09
Tissue Says Blood Is Misleading, Confusing HIV Cure Efforts, Science, vol.334, issue.6063, p.1614, 2011. ,
DOI : 10.1126/science.334.6063.1614
Penetration of Tenofovir and Emtricitabine in Mucosal Tissues: Implications for Prevention of HIV-1 Transmission, Science Translational Medicine, vol.40, issue.9, pp.112-114, 2011. ,
DOI : 10.1086/527387
Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice, Antimicrobial Agents and Chemotherapy, vol.50, issue.12, pp.3998-4004, 2006. ,
DOI : 10.1128/AAC.00625-06
Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance, The Lancet, vol.359, issue.9311, pp.1026-1031, 2002. ,
DOI : 10.1016/S0140-6736(02)08094-7
The HIV Protease Inhibitor Indinavir Impairs Sterol Regulatory Element-Binding Protein-1 Intranuclear Localization, Inhibits Preadipocyte Differentiation, and Induces Insulin Resistance, Diabetes, vol.50, issue.6, pp.1378-1388, 2001. ,
DOI : 10.2337/diabetes.50.6.1378
URL : http://diabetes.diabetesjournals.org/content/diabetes/50/6/1378.full.pdf
HIV protease inhibitors block adipocyte differentiation independently of lamin A/C, AIDS, vol.19, issue.15, pp.1565-1573, 2005. ,
DOI : 10.1097/01.aids.0000186827.91408.90
Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy, Human Molecular Genetics, vol.15, issue.4, pp.653-663, 2006. ,
DOI : 10.1093/hmg/ddi480
URL : https://academic.oup.com/hmg/article-pdf/15/4/653/1800967/ddi480.pdf