D. Barker, X. Liu, and E. Almeida, The BRCA1 and 1A1.3B Promoters Are Parallel Elements of a Genomic Duplication at 17q21, Genomics, vol.38, issue.2, pp.215-222, 1996.
DOI : 10.1006/geno.1996.0618

S. Baylin, J. Herman, J. Gra€, P. Vertino, and J. Issa, Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia, Adv. Cancer Res, vol.72, pp.141-196, 1998.
DOI : 10.1016/S0065-230X(08)60702-2

N. Collins, R. Wooster, and M. Stratton, Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers, British Journal of Cancer, vol.76, issue.9, pp.1150-1156, 1997.
DOI : 10.1038/bjc.1997.526

J. Counts and J. Goodman, Alterations in DNA methylation may play a variety of roles in carcinogenesis, Cell, vol.83, issue.1, pp.13-15, 1995.
DOI : 10.1016/0092-8674(95)90228-7

D. Easton, Breast cancer genes???what are the real risks?, Nature Genetics, vol.11, issue.3, pp.210-211, 1997.
DOI : 10.1038/ng0396-309

L. Friedman, E. Ostermeyer, C. Szabo, P. Dowd, E. Lynch et al., Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families, Nature Genetics, vol.55, issue.4, pp.399-404, 1994.
DOI : 10.1038/ng1294-399

P. Futreal, Q. Liu, D. Shattuck-eidens, C. Cochran, K. Harshman et al., BRCA1 mutations in primary breast and ovarian carcinomas, Science, vol.266, issue.5182, pp.120-122, 1994.
DOI : 10.1126/science.7939630

S. Gayther, W. Warren, S. Mazoyer, P. Russell, P. Harrington et al., Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype???phenotype correlation, Nature Genetics, vol.2, issue.4, pp.428-433, 1995.
DOI : 10.1038/359794a0

R. Hakem, J. De-la-pompa, C. Sirard, M. Mo, A. Hakem et al., The Tumor Suppressor Gene Brca1 Is Required for Embryonic Cellular Proliferation in the Mouse, Cell, vol.85, issue.7, pp.1009-1023, 1996.
DOI : 10.1016/S0092-8674(00)81302-1

P. Laird and R. Jaenisch, DNA methylation and cancer, Human Molecular Genetics, vol.3, issue.suppl_1, pp.1487-1495, 1994.
DOI : 10.1093/hmg/3.suppl_1.1487

S. Marquis, J. Rajan, A. Wynshaw-boris, J. Xu, G. Yin et al., The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues, Nature Genetics, vol.18, issue.1, pp.17-26, 1995.
DOI : 10.1038/ng1192-240

S. Merajver, T. Pham, R. Cadu€, M. Chen, E. Poy et al., Somatic mutations in the BRCA1 gene in sporadic ovarian tumours, Nature Genetics, vol.2, issue.4, pp.439-443, 1995.
DOI : 10.1016/S0140-6736(94)91578-4

Y. Miki, J. Swensen, D. Shattuck-eidens, A. Futreal, K. Harshman et al., A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1, Science, vol.266, issue.5182, pp.66-71, 1994.
DOI : 10.1126/science.7545954

H. Poulsen, C. Taylor, and L. Sobin, Histological typing of female genital tract tumors International histological classification of tumors, Geneva, vol.13, 1975.

S. Ribieras, F. Magdinier, D. Leclerc, G. Lenoir, L. Frappart et al., Abundance ofBRCA1 transcripts in human cancer and lymphoblastoid cell lines carryingBRCA1 germ-line alterations, International Journal of Cancer, vol.14, issue.5, pp.715-718, 1997.
DOI : 10.1038/sj.onc.1200924
URL : http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1097-0215(19971127)73:5<715::AID-IJC17>3.0.CO;2-4/pdf

S. Ribieras, X. Song-wang, V. Martin, P. Lointier, L. Frappart et al., Human breast and colon cancers exhibit alterations of DNA methylation patterns at several DNA segments on chromosomes 11p and 17p, Journal of Cellular Biochemistry, vol.53, issue.1, pp.86-96, 1994.
DOI : 10.1016/0167-4781(84)90043-5

J. Sambrook, E. Fristsch, and T. Maniatis, In: Molecular cloning: a laboratory manual, 1989.

R. Scully, J. Chen, A. Plug, Y. Xiao, D. Weaver et al., Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells, Cell, vol.88, issue.2, pp.265-275, 1997.
DOI : 10.1016/S0092-8674(00)81847-4

S. Smith, D. Easton, D. Evans, and B. Ponder, Allele losses in the region 17q12???21 in familial breast and ovarian cancer involve the wild???type chromosome, Nature Genetics, vol.18, issue.2, pp.128-131, 1992.
DOI : 10.1038/342177a0

T. Smith, K. Ming, C. Szabo, N. Jerome, M. Mceuen et al., Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1., Genome Research, vol.6, issue.11, pp.1029-1049, 1996.
DOI : 10.1101/gr.6.11.1029

M. Thompson, R. Jensen, P. Obermiller, D. Page, and J. Holt, Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression, Nature Genetics, vol.8, issue.4, pp.444-450, 1995.
DOI : 10.1128/MCB.8.2.963

P. Warnecke, C. Stirzaker, J. Melki, D. Millar, C. Paul et al., Detection and measurement of PCR bias in quantitative methylation analysis of bisulphite-treated DNA, Nucleic Acids Research, vol.25, issue.21, pp.4422-4426, 1997.
DOI : 10.1093/nar/25.21.4422