Insulator dynamics and the setting of chromatin domains

Abstract : The early discovery of cis-regulatory elements able to promote transcription of genes over large distances led to the postulate that elements, termed insulators, should also exist that would limit the action of enhancers, LCRs and silencers to defined domains. Such insulators were indeed found during the past fifteen years in a wide range of organisms, from yeast to humans. Recent advances point to an important role of transcription factors in insulator activity and demonstrate that the operational observation of an insulator effect relies on a delicate balance between the "efficiency" of the insulator and that of the element to be counteracted. In addition, genuine insulator elements now appear less common than initially envisaged, and they are only found at loci displaying a high density of coding or regulatory information. Where this is not the case, chromatin domains of opposing properties are thought to confront each other at "fuzzy" boundaries. In this article, we propose models for both fixed and fuzzy boundaries that incorporate probabilistic and dynamic parameters.
Liste complète des métadonnées

Littérature citée [99 références]  Voir  Masquer  Télécharger

https://hal-amu.archives-ouvertes.fr/hal-01663885
Contributeur : Frederique Magdinier <>
Soumis le : jeudi 14 décembre 2017 - 12:52:41
Dernière modification le : vendredi 4 mai 2018 - 18:00:02

Fichier

Fourel_et_al-2004-BioEssays.pd...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Geneviève Fourel, Frédérique Magdinier, Eric Gilson. Insulator dynamics and the setting of chromatin domains. BioEssays, Wiley-VCH Verlag, 2004, 26 (5), pp.523-532. 〈10.1002/bies.20028〉. 〈hal-01663885〉

Partager

Métriques

Consultations de la notice

106

Téléchargements de fichiers

45