Ruthenium-Catalyzed [2+2+2] Cycloaddition of 1,6-Enynes and Unactivated Alkynes: Access to Ring-Fused Cyclohexadienes

Rui Liu (1) , Laurent Giordano (1) , Alphonse Tenaglia (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

The [2+2+2] intermolecular carbocyclization reactions between 1,6-enynes and alkynes catalyzed by [RuCl-(cod)(Cp*)] (cod = 1,5-cyclooctadiene, Cp* = pentamethylcy-clopentadienyl) are reported to provide bicyclohexa-1,3-dienes. The presented reaction conditions are compatible with internal and terminal alkynes and the chemo-and re-gioselectivity issues are controlled by the presence of sub-stituents at the propargyl carbon center of the alkyne(s) partner(s).

Domaines: Chimie organique; Catalyse

Rui Liu, Laurent Giordano, Alphonse Tenaglia. Ruthenium-Catalyzed [2+2+2] Cycloaddition of 1,6-Enynes and Unactivated Alkynes: Access to Ring-Fused Cyclohexadienes. Chemistry - An Asian Journal, 2017, 12 (17), pp.2245-2257. ⟨10.1002/asia.201700642⟩. ⟨hal-01682722⟩