Bicatalyzed Three-Component Stereoselective Decarboxylative Fluoro-Aldolization for the Construction of Elongated Fluorohydrins

Adrien Quintard (1) , Jean Rodriguez (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

A bicatalyzed three-component cascade between simple aliphatic enolizable aldehydes, a fluorine source, and keto acids has allowed the diastereoselective and enantioselective direct synthesis of carbonyl-elongated vicinal fluorohydrins. The obtained complex acyclic functionalized molecules, possessing up to four stereogenic centers controlled in usually >95% ee, hold great promise for further synthetic developments and rapid incorporation in bioactive elaborated structures.

Mots clés: enantioselectivity; fluorination; copper catalysis; organocatalysis; cascade

Domaines: Chimie organique

Adrien Quintard, Jean Rodriguez. Bicatalyzed Three-Component Stereoselective Decarboxylative Fluoro-Aldolization for the Construction of Elongated Fluorohydrins. ACS Catalysis, 2017, 7 (8), pp.5513-5517. ⟨10.1021/acscatal.7b02353⟩. ⟨hal-01687102⟩