Enantioselective syntheses of atropisomers featuring a five-membered ring

Damien Bonne (1) , Jean Rodriguez (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

Atropisomerism is a fundamental property of molecules featuring a hindered rotation around a chemical bond. If six-membered ring biaryl or heterobiaryl atropisomers are the most popular ones, the focus of this feature article will be put on less common and more challenging five-membered ring containing atropisomers displaying either a stereogenic C–N or C–C bond. After an historical background, a description of the latest flourishing enantioselective strategies for the construction of this attractive family of atropisomers will be presented.

Domaines: Chimie organique

Damien Bonne, Jean Rodriguez. Enantioselective syntheses of atropisomers featuring a five-membered ring. Chemical Communications, 2017, 53 (92), pp.12385-12393. ⟨10.1039/c7cc06863h⟩. ⟨hal-01687197⟩