M. Bissell and D. Radisky, Putting tumours in context, Nature Reviews Cancer, vol.1, issue.1, pp.46-54, 2001.
DOI : 10.1038/35094059

D. Hanahan and R. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011.
DOI : 10.1016/j.cell.2011.02.013

N. Bhowmick, A. Chytil, D. Plieth, A. Gorska, N. Dumont et al., TGF-?? Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia, Science, vol.303, issue.5659, pp.848-851, 2004.
DOI : 10.1126/science.1090922

L. Coussens and Z. Werb, Inflammation and cancer, Nature, vol.2, issue.6917, pp.860-867, 2002.
DOI : 10.1038/nm0396-287

T. Jacobs, C. Byrne, G. Colditz, J. Connolly, and S. Schnitt, Radial Scars in Benign Breast-Biopsy Specimens and the Risk of Breast Cancer, New England Journal of Medicine, vol.340, issue.6, pp.430-436, 1999.
DOI : 10.1056/NEJM199902113400604

A. Olumi, G. Grossfeld, S. Hayward, P. Carroll, T. Tlsty et al., Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium, Cancer Res, vol.59, pp.5002-5011, 1999.

N. Bhowmick, E. Neilson, and H. Moses, Stromal fibroblasts in cancer initiation and progression, Nature, vol.124, issue.suppl. 1, pp.332-337, 2004.
DOI : 10.1002/jez.1401750405

R. Kalluri and M. Zeisberg, Fibroblasts in cancer, Nature Reviews Cancer, vol.59, issue.Suppl. 3, pp.392-401, 2006.
DOI : 10.1046/j.1523-1755.2001.059002543.x

A. Trimboli, C. Cantemir-stone, F. Li, J. Wallace, A. Merchant et al., Pten in stromal fibroblasts suppresses mammary epithelial tumours, Nature, vol.27, issue.7267, pp.1084-1091, 2009.
DOI : 10.1177/002215540305100613

M. Allinen, R. Beroukhim, L. Cai, C. Brennan, J. Lahti-domenici et al., Molecular characterization of the tumor microenvironment in breast cancer, Cancer Cell, vol.6, issue.1, pp.17-32, 2004.
DOI : 10.1016/j.ccr.2004.06.010

A. Orimo, P. Gupta, D. Sgroi, F. Arenzana-seisdedos, T. Delaunay et al., Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion, Cell, vol.121, issue.3, pp.335-348, 2005.
DOI : 10.1016/j.cell.2005.02.034

Y. Crawford, I. Kasman, L. Yu, C. Zhong, X. Wu et al., PDGF-C Mediates the Angiogenic and Tumorigenic Properties of Fibroblasts Associated with Tumors Refractory to Anti-VEGF Treatment, Cancer Cell, vol.15, issue.1, pp.21-34, 2009.
DOI : 10.1016/j.ccr.2008.12.004

A. Desmouliere, C. Guyot, and G. Gabbiani, The stroma reaction myofibroblast: a key player in the control of tumor cell behavior, The International Journal of Developmental Biology, vol.48, issue.5-6, pp.509-517, 2004.
DOI : 10.1387/ijdb.041802ad

H. Sugimoto, T. Mundel, M. Kieran, and R. Kalluri, Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biology & Therapy, vol.5, issue.12, pp.1640-1646, 2006.
DOI : 10.4161/cbt.5.12.3354

L. Mclatchie, N. Fraser, M. Main, A. Wise, J. Brown et al., RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor, Nature, vol.141, issue.6683, pp.333-339, 1998.
DOI : 10.1084/jem.183.6.2437

D. Poyner, P. Sexton, I. Marshall, D. Smith, R. Quirion et al., International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors, Pharmacological Reviews, vol.54, issue.2, pp.233-246, 2002.
DOI : 10.1124/pr.54.2.233

J. Hinson, S. Kapas, and D. Smith, Adrenomedullin, a Multifunctional Regulatory Peptide, Endocrine Reviews, vol.21, issue.2, pp.138-167, 2000.
DOI : 10.1210/er.21.2.138

J. Lopez and A. Martinez, Cell and molecular biology of the multifunctional peptide, adrenomedullin, Int Rev Cytol, vol.221, pp.1-92, 2002.
DOI : 10.1016/S0074-7696(02)21010-4

E. Zudaire, A. Martinez, and F. Cuttitta, Adrenomedullin and cancer, Regulatory Peptides, vol.112, issue.1-3, pp.175-183, 2003.
DOI : 10.1016/S0167-0115(03)00037-5

M. Miller, A. Martínez, E. Unsworth, C. Thiele, T. Moody et al., Adrenomedullin Expression in Human Tumor Cell Lines ITS POTENTIAL ROLE AS AN AUTOCRINE GROWTH FACTOR, Journal of Biological Chemistry, vol.92, issue.38, pp.23345-23351, 1996.
DOI : 10.1172/JCI113594

L. Ouafik, S. Sauze, F. Boudouresque, O. Chinot, C. Delfino et al., Neutralization of Adrenomedullin Inhibits the Growth of Human Glioblastoma Cell Lines in Vitro and Suppresses Tumor Xenograft Growth in Vivo, The American Journal of Pathology, vol.160, issue.4, pp.1279-1292, 2002.
DOI : 10.1016/S0002-9440(10)62555-2

URL : https://hal.archives-ouvertes.fr/inserm-00151079

E. Nouguerède, C. Berenguer, S. Garcia, B. Bennani, C. Delfino et al., Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo, Cancer Medicine, vol.91, issue.Suppl. 1, pp.196-207, 2013.
DOI : 10.1161/01.RES.0000036603.61868.F9

C. Berenguer-daize, F. Boudouresque, C. Bastide, A. Tounsi, Z. Benyahia et al., Adrenomedullin Blockade Suppresses Growth of Human Hormone-Independent Prostate Tumor Xenograft in Mice, Clinical Cancer Research, vol.19, issue.22, pp.6138-6150, 2013.
DOI : 10.1158/1078-0432.CCR-13-0691

URL : https://hal.archives-ouvertes.fr/hal-01460433

T. Ishikawa, J. Chen, J. Wang, F. Okada, T. Sugiyama et al., Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis, Oncogene, vol.22, issue.8, pp.1238-1242, 2003.
DOI : 10.1038/35025215

I. Kaafarani, S. Fernandez-sauze, C. Berenguer, O. Chinot, C. Delfino et al., Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice, The FASEB Journal, vol.23, issue.10, pp.3424-3435, 2009.
DOI : 10.1016/S0301-472X(02)00890-1

V. Ramachandran, T. Arumugam, R. Hwang, J. Greenson, D. Simeone et al., Adrenomedullin Is Expressed in Pancreatic Cancer and Stimulates Cell Proliferation and Invasion in an Autocrine Manner via the Adrenomedullin Receptor, ADMR, Cancer Research, vol.67, issue.6, pp.2666-2675, 2007.
DOI : 10.1158/0008-5472.CAN-06-3362

E. Zudaire, A. Martinez, M. Garayoa, R. Pio, G. Kaur et al., Adrenomedullin Is a Cross-Talk Molecule that Regulates Tumor and Mast Cell Function during Human Carcinogenesis, The American Journal of Pathology, vol.168, issue.1, pp.280-291, 2006.
DOI : 10.2353/ajpath.2006.050291

P. Chen, Y. Huang, R. Bong, Y. Ding, N. Song et al., Tumor-Associated Macrophages Promote Angiogenesis and Melanoma Growth via Adrenomedullin in a Paracrine and Autocrine Manner, Clinical Cancer Research, vol.17, issue.23, pp.7230-7239, 2011.
DOI : 10.1158/1078-0432.CCR-11-1354

T. Huang and T. Chu, Repression of miR-126 and upregulation of adrenomedullin in the stromal endothelium by cancer-stromal cross talks confers angiogenesis of cervical cancer, Oncogene, vol.63, issue.28, pp.3636-3647, 2014.
DOI : 10.1111/j.1349-7006.2009.01285.x

T. Roszer, Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms, Mediators of Inflammation, vol.266, issue.14, pp.1-16
DOI : 10.1016/j.fsi.2013.07.042

A. Bolling, J. Ovrevik, J. Samulsen, J. Holme, K. Rakkestad et al., Mono-2-ethylphthalate (MEHP) induces TNF-? release and macrophage differentiation through different signalling pathways in RAW264.7 cells. Toxicology letters, pp.43-50, 2012.

L. Kunz-schughart, A. Weber, M. Rehli, E. Gottfried, G. Brockhoff et al., The classical macrophage marker CD68 is strongly expressed in primary human fibroblasts. [Article in German], Verh Dtsch Ges Pathol, vol.87, pp.215-223, 2003.

T. Inoue, D. Plieth, C. Venkov, C. Xu, and E. Neilson, Antibodies against macrophages that overlap in specificity with fibroblasts, Kidney International, vol.67, issue.6, pp.2488-2493, 2005.
DOI : 10.1111/j.1523-1755.2005.00358.x

G. Serini and G. Gabbiani, Mechanisms of Myofibroblast Activity and Phenotypic Modulation, Experimental Cell Research, vol.250, issue.2, pp.273-283, 1999.
DOI : 10.1006/excr.1999.4543

H. Dvorak, Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N Engl J Med, vol.315, pp.1650-1659, 1986.

Y. Kojima, A. Acar, E. Eaton, K. Mellody, C. Scheel et al., Autocrine TGF-?? and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts, Proceedings of the National Academy of Sciences, vol.52, issue.24, pp.20009-20014, 2010.
DOI : 10.1016/0305-7372(95)90038-1

N. Ilan, S. Mahooti, and J. Madri, Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis, J Cell Sci, vol.111, pp.3621-3631, 1998.

S. Fernandez-sauze, C. Delfino, K. Mabrouk, C. Dussert, O. Chinot et al., Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: Involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors, International Journal of Cancer, vol.88, issue.6, pp.797-804, 2004.
DOI : 10.1161/01.CIR.90.2.649

P. Mishra, P. Mishra, R. Humeniuk, D. Medina, G. Alexe et al., Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells, Cancer Research, vol.68, issue.11, pp.4331-4339, 2008.
DOI : 10.1158/0008-5472.CAN-08-0943

A. Orimo and R. Weinberg, Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type, Cell Cycle, vol.5, issue.15, pp.1597-601, 2006.
DOI : 10.4161/cc.5.15.3112

I. Haviv, K. Polyak, W. Qiu, M. Hu, and I. Campbell, Origin of carcinoma associated fibroblasts, Cell Cycle, vol.8, issue.4, pp.589-595, 2009.
DOI : 10.4161/cc.8.4.7669

R. Weinberg, Coevolution in the tumor microenvironment, Nature Genetics, vol.6, issue.5, pp.494-495, 2008.
DOI : 10.1056/NEJM198612253152606

K. Polyak, I. Haviv, and I. Campbell, Co-evolution of tumor cells and their microenvironment, Trends in Genetics, vol.25, issue.1, pp.30-38, 2009.
DOI : 10.1016/j.tig.2008.10.012

A. Martinez, M. Vos, L. Guédez, G. Kaur, Z. Chen et al., The Effects of Adrenomedullin Overexpression in Breast Tumor Cells, CancerSpectrum Knowledge Environment, vol.94, issue.16, pp.1226-1237, 2002.
DOI : 10.1093/jnci/94.16.1226

L. Nikitenko, S. Fox, S. Kehoe, M. Rees, and R. Bicknell, Adrenomedullin and tumour angiogenesis, British Journal of Cancer, vol.112, issue.1, pp.1-7, 2006.
DOI : 10.1016/S0167-0115(03)00037-5

URL : http://doi.org/10.1038/sj.bjc.6602832

G. Khalfaoui-bendriss, N. Dussault, S. Fernandez-sauze, C. Berenguer-daizé, R. Sigaud et al., Adrenomedullin blockade induces regression of tumor neovessels through interference with vascular endothelialcadherin signalling, Oncotarget, vol.6, pp.7536-7553, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01410286

K. Kinzler and B. Vogelstein, ONCOGENESIS: Landscaping the Cancer Terrain, Science, vol.280, issue.5366, pp.1036-1037, 1998.
DOI : 10.1126/science.280.5366.1036

N. Hayashi, G. Cunha, and Y. Wong, Influence of male genital tract mesenchymes on differentiation of dunning prostatic adenocarcinoma, Cancer Res, vol.50, pp.4747-4754, 1990.

O. Picard, Y. Rolland, and M. Poupon, Fibroblast-dependent tumorigenicity of cells in nude mice: implication for implantation of metastases, Cancer Res, vol.46, pp.3290-3294, 1986.

R. Kalluri, The biology and function of fibroblasts in cancer, Nature Reviews Cancer, vol.9, issue.9, pp.582-598, 2016.
DOI : 10.1371/journal.pgen.1003789

B. Hinz, S. Phan, V. Thannickal, A. Galli, M. Bochaton-piallat et al., The Myofibroblast, The American Journal of Pathology, vol.170, issue.6, pp.1807-1816, 2007.
DOI : 10.2353/ajpath.2007.070112

URL : https://hal.archives-ouvertes.fr/hal-00661272

T. Kisseleva and D. Brenner, Mechanisms of Fibrogenesis, Experimental Biology and Medicine, vol.233, issue.2, pp.109-122, 2008.
DOI : 10.1007/BF02890172

C. Buckley, D. Pilling, J. Lord, A. Akbar, D. Scheel-toellner et al., Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation, Trends in Immunology, vol.22, issue.4, pp.199-204, 2001.
DOI : 10.1016/S1471-4906(01)01863-4

R. Smith, T. Smith, T. Blieden, and R. Phipps, Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation, Am J Pathol, vol.151, pp.317-322, 1997.

N. Erez, M. Truitt, P. Olson, S. Arron, and D. Hanahan, Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-??B-Dependent Manner, Cancer Cell, vol.17, issue.2, pp.135-182, 2010.
DOI : 10.1016/j.ccr.2009.12.041

P. Gallagher, Y. Bao, A. Prorock, P. Zigrino, R. Nischt et al., Gene Expression Profiling Reveals Cross-talk between Melanoma and Fibroblasts: Implications for Host-Tumor Interactions in Metastasis, Cancer Research, vol.65, issue.10, pp.4134-4146, 2005.
DOI : 10.1158/0008-5472.CAN-04-0415

L. Mueller, F. Goumas, M. Affeldt, S. Sandtner, U. Gehling et al., Stromal Fibroblasts in Colorectal Liver Metastases Originate From Resident Fibroblasts and Generate an Inflammatory Microenvironment, The American Journal of Pathology, vol.171, issue.5, pp.1608-1618, 2007.
DOI : 10.2353/ajpath.2007.060661

T. Silzle, M. Kreutz, M. Dobler, G. Brockhoff, R. Knuechel et al., Tumor-associated fibroblasts recruit blood monocytes into tumor tissue, European Journal of Immunology, vol.33, issue.5, pp.1311-1320, 2003.
DOI : 10.1002/eji.200323057

URL : http://onlinelibrary.wiley.com/doi/10.1002/eji.200323057/pdf

M. Augsten, C. Hägglöf, E. Olsson, C. Stolz, P. Tsagozis et al., CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth, Proceedings of the National Academy of Sciences, vol.25, issue.35, pp.3414-3419, 2009.
DOI : 10.1038/sj.onc.1209497

P. Micke, K. Kappert, M. Ohshima, C. Sundquist, S. Scheidl et al., In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma, Journal of Investigative Dermatology, vol.127, issue.6, pp.1516-1523, 2007.
DOI : 10.1038/sj.jid.5700714

K. Pietras, J. Pahler, G. Bergers, and D. Hanahan, Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting, PLoS Medicine, vol.11, issue.1, p.19, 2008.
DOI : 10.1371/journal.pmed.0050019.st002

N. Israel and S. Saez, Relation between steroid receptor content and the response to hormone addition in isolated human breast cancer cells in short-term culture, Cancer Res, vol.38, pp.4314-4317, 1978.

C. Berenguer, F. Boudouresque, C. Dussert, L. Daniel, X. Muracciole et al., Adrenomedullin, an autocrine/paracrine factor induced by androgen withdrawal, stimulates ???neuroendocrine phenotype??? in LNCaP prostate tumor cells, Oncogene, vol.61, issue.4, pp.506-518, 2008.
DOI : 10.1002/(SICI)1097-0045(20000215)42:3<186::AID-PROS4>3.0.CO;2-E

J. Deville, C. Bartoli, C. Berenguer, S. Fernandez-sauze, I. Kaafarani et al., Expression and role of adrenomedullin in renal tumors and value of its mRNA levels as prognostic factor in clear-cell renal carcinoma, International Journal of Cancer, vol.31, issue.10, pp.2307-2315, 2009.
DOI : 10.1152/ajpregu.00274.2003

N. Weidner, J. Semple, W. Welch, and J. Folkman, Tumor Angiogenesis and Metastasis ??? Correlation in Invasive Breast Carcinoma, New England Journal of Medicine, vol.324, issue.1, pp.1-8, 1991.
DOI : 10.1056/NEJM199101033240101