TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion

Agathe Oulidi (1) , Alexandre Bokhobza (1) , Dimitra Gkika (1) , Fabien Vanden Abeele (1) , V'Yacheslav Lehen'Kyi (1) , L’houcine Ouafik (2) , Brigitte Mauroy (1) , Natalia Prevarskaya (1)

1 Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
2 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie

Adrenomedullin (AM) is a 52-amino acid peptide initially isolated from human pheochromocytoma. AM is expressed in a variety of malignant tissues and cancer cell lines and was shown to be a mitogenic factor capable of stimulating growth of several cancer cell types. In addition, AM is a survival factor for certain cancer cells. Some data suggest that AM might be involved in the progression cancer metastasis via angiogenesis and cell migration and invasion control. The Transient Receptor Potential channel TRPV2 is known to promote in prostate cancer cell migration and invasive phenotype and is correlated with the stage and grade of bladder cancer. In this work we show that AM induces prostate and urothelial cancer cell migration and invasion through TRPV2 translocation to plasma membrane and the subsequent increase in resting calcium level.

Domaines: Cancer

Agathe Oulidi, Alexandre Bokhobza, Dimitra Gkika, Fabien Vanden Abeele, V'Yacheslav Lehen'Kyi, et al.. TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion. PLoS ONE, 2013, 8 (5), pp.e64885. ⟨10.1371/journal.pone.0064885⟩. ⟨hal-01708095⟩