Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats

Fabrice Tranchida (1) , Zo Rakotoniaina (1) , Laetitia Shintu (1) , Léopold Tchiakpe (2) , Valérie Deyris (1) , Mehdi Yemloul (1) , Pierre Stocker (3) , Nicolas Vidal (3) , Odile Rimet (2) , Abel Hiol (4) , Stefano Caldarelli (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 AMU PHARM - Aix-Marseille Université - Faculté de pharmacie
3 ICR - Institut de Chimie Radicalaire
4 Qualisud Réunion - Qualisud - Pôle de La Réunion

The metabolic effects of an oral supplementation with a Curcuma longa extract, at a dose nutritionally relevant with common human use, on hepatic metabolism in rats fed a high fructose and saturated fatty acid (HFS) diet was evaluated. High-resolution magic-angle spinning NMR and GC/MS in combination with multivariate analysis have been employed to characterize the NMR metabolite profiles and fatty acid composition of liver tissue respectively. The results showed a clear discrimination between HFS groups and controls involving metabolites such as glucose, glycogen, amino acids, acetate, choline, lysophosphatidylcholine, phosphatidylethanolamine, and β-hydroxybutyrate as well as an increase of MUFAs and a decrease of n-6 and n-3 PUFAs. Although the administration of CL did not counteract deleterious effects of the HFS diet, some metabolites, namely some n-6 PUFA and n-3 PUFA, and betaine were found to increase significantly in liver samples from rats having received extract of curcuma compared to those fed the HFS diet alone. This result suggests that curcuminoids may affect the transmethylation pathway and/or osmotic regulation. CL extract supplementation in rats appears to increase some of the natural defences preventing the development of fatty liver by acting on the choline metabolism to increase fat export from the liver.

Domaines: Alimentation et Nutrition; Endocrinologie et métabolisme

Fabrice Tranchida, Zo Rakotoniaina, Laetitia Shintu, Léopold Tchiakpe, Valérie Deyris, et al.. Hepatic metabolic effects of Curcuma longa extract supplement in high-fructose and saturated fat fed rats. Scientific Reports, 2017, 7, pp.5880. ⟨10.1038/s41598-017-06220-0⟩. ⟨hal-01734918⟩