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Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines

Abstract : Oxaliplatin is the first platinum-based compound effective in the treatment of colorectal cancer. Oxaliplatin combined with cetuximab for metastatic colorectal cancer is under evaluation. The preliminary results seem controversial, particularly for the use of cetuximab in K-Ras mutated patients. K-Ras mutation is known to affect redox homeostasis. Here we evaluated how the efficacy of oxaliplatin alone or combined with cetuximab varied according to the Ras mutation and redox status in a panel of colorectal tumour cell lines.
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Submitted on : Tuesday, March 27, 2018 - 3:53:12 PM
Last modification on : Thursday, June 11, 2020 - 3:20:28 AM

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Laetitia Dahan, Amine Sadok, Jean-Louis Formento, Jean François Seitz, Hervé Kovacic. Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines. British Journal of Pharmacology, Wiley, 2009, 158 (2), pp.610 - 620. ⟨10.1111/j.1476-5381.2009.00341.x⟩. ⟨hal-01744726⟩

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