Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

Pooja R Mandaviya , Roby Joehanes , Dylan Aïssi (1) , Brigitte Kühnel , Riccardo E Marioni , Vinh Truong (2) , Lisette Stolk , Marian Beekman (3) , Jan Bonder , Lude Franke , Christian Gieger (4) , Tianxiao Huan , M. Arfan Arfan Ikram (5) , Sonja Kunze , Liming Liang (6) , Jan Lindemans , Chunyu Liu (7) , Allan F Mcrae , Michael Mendelson , Martina Müller-Nurasyid , Annette Peters (8) , P. Eline Eline Slagboom (9) , John M Starr , David-Alexandre Trégouët (1) , Andre Uitterlinden (10) , Marleen M J van Greevenbroek , Diana van Heemst (11) , Maarten van Iterson , Philip S Wells , Chen Yao , Ian J Deary (5) , France Gagnon (2) , Bastiaan T Heijmans , Daniel Lévy (12) , Pierre-Emmanuel Morange (13, 14) , Melanie Waldenberger , Sandra G Heil , Joyce B J van Meurs , Tanja Zeller (15) , Brigitte Kü Hnel , Marc Jan Bonder , David-Alexandre Tré Gouë T , André G Uitterlinden

1 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
2 University of Toronto
3 Molecular Epidemiology
4 Institute of Experimental Medicine
5 Metacohorts Consortium
6 Harvard T.H. Chan School of Public Health
7 Bioinformatics Research Center
8 Center For Narcolepsy
9 Leiden University Medical Center (LUMC)
10 Internal Medicine
11 Department of neurology
12 PSE - Paris-Jourdan Sciences Economiques
13 Fibrinolyse et Pathologie Vasculaire
14 NORT - Nutrition, obésité et risque thrombotique
15 University Heart Center Hamburg

Background

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology

Pooja R Mandaviya, Roby Joehanes, Dylan Aïssi, Brigitte Kühnel, Riccardo E Marioni, et al.. Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes. PLoS ONE, 2017, 12 (10), ⟨10.1371/journal.pone.0182472⟩. ⟨hal-01749929⟩