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Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

Abstract : Aim: Homocysteine (Hcy) is a sensitive marker of one-carbon metabolism. Higher Hcy levels have been associated with global DNA hypomethylation. We investigated the association between plasma Hcy and epigenome-wide DNA methylation in leukocytes. Methods: Methylation was measured using Illumina 450 k arrays in 2035 individuals from six cohorts. Hcy-associated differentially methylated positions and regions were identified using meta-analysis. Results: Three differentially methylated positions cg21607669 (SLC27A1), cg26382848 (AJUBA) and cg10701000 (KCNMA1) at chromosome 19, 14 and 10, respectively, were significantly associated with Hcy. In addition, we identified 68 Hcy-associated differentially methy-lated regions, the most significant of which was a 1.8-kb spanning domain (TNXB/ATF6B) at chromosome 6. Conclusion: We identified novel epigenetic loci associated with Hcy levels, of which specific role needs to be further validated.
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Submitted on : Wednesday, April 11, 2018 - 6:07:22 PM
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Pooja Mandaviya, Dylan Aïssi, Koen Dekkers, Roby Joehanes, Silva Kasela, et al.. Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics, Future Medicine, 2017, 9 (11), pp.1403-1422. ⟨10.2217/epi-2017-0038⟩. ⟨hal-01753870⟩

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